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CDK-IN-2

Names

[ CAS No. ]:
1269815-17-9

[ Name ]:
CDK-IN-2

[Synonym ]:
(R)-piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxyphenyl)-pyridin-2-yl]-amide
(R)-N-(5-chloro-4-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)piperidine-3-carboxamide trifluoroacetate
CDK inhibitor II|
CDK-IN-2

Biological Activity

[Description]:

CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4.IC50 Value: <8 nM [1]Target: CDK9In vitro:In vivo:

[Related Catalog]:

Research Areas >> Cancer

[Target]

CDK9/cyclinT1:8 nM (IC50)


[References]

[1]. Keith B Pfister, et al. Heteroaryl compounds as kinase inhibitors. 2011, WO2011026917A1.


[Related Small Molecules]

Abemaciclib(LY2835219) | Ribociclib (LEE011) | Dinaciclib (SCH727965) | THZ1 2HCl | Roscovitine (CYC202) | THZ531 | RO-3306 | Flavopiridol | NVP 2 | BAY-1143572 Racemate | CYC-065 | AZD5438 | BIO | Kenpaullone | SNS-032 (BMS-387032)

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19ClFN3O2

[ Molecular Weight ]:
363.81400

[ Exact Mass ]:
363.11500

[ PSA ]:
66.74000

[ LogP ]:
4.46610

[ Storage condition ]:
2-8℃

Related Compounds