Bis-propargyl-PEG3

Names

[ Name ]:
Bis-propargyl-PEG3

[Synonym ]:
4,7,10,13-tetraoxahexadeca-1,15-diyne
4,7,10,13-tetraoxa-hexadeca-1,15-diine
Bis-propargyl-PEG3

Biological Activity

[Description]:

Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity[1] [2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity against three strains of Plasmodium falciparum [2].

[References]

[1]. Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.

[2]. Rice DR, et al. Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes. Bioorg Med Chem. 2017 May 15;25(10):2754-2760.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₈O₄

[ Molecular Weight ]:
226.26900

[ Exact Mass ]:
226.12100

[ PSA ]:
36.92000

[ LogP ]:
0.31920

Precursor & DownStream

Precursor

DownStream

Related Compounds

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