Bis-propargyl-PEG4

Names

[ Name ]:
Bis-propargyl-PEG4

[Synonym ]:
MFCD22201533
4,7,10,13,16-Pentaoxanonadeca-1,18-diyne

Biological Activity

[Description]:

Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

Bis-propargyl-PEG4 can be used in the synthesis of demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis[2].

[References]

[1]. Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.

[2]. Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
338.7±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₂O₅

[ Molecular Weight ]:
270.322

[ Flash Point ]:
130.7±26.4 °C

[ Exact Mass ]:
270.146729

[ LogP ]:
-0.41

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.463

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.