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Biotin-PEG3-NHS ester

Names

[ CAS No. ]:
1253286-56-4

[ Name ]:
Biotin-PEG3-NHS ester

[Synonym ]:
MFCD11974977
N-{2-[2-(2-{3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy}ethoxy)ethoxy]ethyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[2-[2-[2-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]ethoxy]ethoxy]ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)-

Biological Activity

[Description]:

Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C23H36N4O9S

[ Molecular Weight ]:
544.618

[ Exact Mass ]:
544.220276

[ LogP ]:
-2.93

[ Index of Refraction ]:
1.574

Related Compounds