Prednisolone Sodium Phosphate

Names

[ CAS No. ]:
125-02-0

[ Name ]:
Prednisolone Sodium Phosphate

[Synonym ]:
(11beta)
Phortisolone
disodium 2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl phosphate
Inflamase
prednisolon disodium phosphate
Prednisolone sodium phosphate
Optival
Predsol
Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11β)-
11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(Disodium phosphate)
Codelsol
Prednisolone (disodium phosphate)
prednisolone 21-disodium phosphate
Prednisolone 21-Phosphate Disodium Salt
MFCD07776968
11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(disodium phosphate)
phosphate de 2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-diméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yl]-2-oxoéthyle de disodium
METRETON
Prozorin
Disodium Prednisolone 21-Phosphate
EINECS 204-722-9
Solucort
Dinatrium-2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethylphosphat
Predsolan
Prednesol
Dojilon
Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, sodium salt, (11β)- (1:2)
Disodium (11β)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl phosphate
Ak-pred

Biological Activity

[Description]:

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

Research Areas >> Inflammation/Immunology

[References]

[1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95.

[2]. http://en.wikipedia.org/wiki/Prednisolone

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
100 °C

[ Molecular Formula ]:
C₂₁H₂₇Na₂O₈P

[ Molecular Weight ]:
484.388

[ Flash Point ]:
361.9ºC

[ Exact Mass ]:
484.123901

[ PSA ]:
156.83000

[ LogP ]:
2.55100

[ Vapour Pressure ]:
4.17E-21mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4153300

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(dihydrogen phosphate), disodium salt

CAS REGISTRY NUMBER :: 125-02-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H27-O8-P.2Na

MOLECULAR WEIGHT :: 484.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 22,1439,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5598 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2937229000

Customs

[ HS Code ]: 2937229000

Related Compounds

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