2-Amino-2-methyl-1-propanol

Names

[ CAS No. ]:
124-68-5

[ Name ]:
2-Amino-2-methyl-1-propanol

[Synonym ]:
2-Amino-2-methyl-1-propanol
2,2-Dimethyl-ethanolamine
EINECS 204-709-8
2-Amino-2-methyl-propan-1-ol
2-Amino-2-Methylpropan-1-Ol
MFCD00008051
Aminomethyl propanol
1,1-Dimethyl-2-hydroxyethylamine
1-Propanol, 2-amino-2-methyl-

Biological Activity

[Description]:

2-Amino-2-methyl-1-propanol (AMP) is a neutralizer, buffer and surfactant[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Hong NS, et al. Rapid and accurate determination of deoxyribonucleoside monophosphates from DNA using micellar electrokinetic chromatography with a cationic surfactant additive. Anal Bioanal Chem. 2011 Jun;400(7):2131-40.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
167.2±13.0 °C at 760 mmHg

[ Melting Point ]:
24-28 °C(lit.)

[ Molecular Formula ]:
C₄H₁₁NO

[ Molecular Weight ]:
89.14

[ Flash Point ]:
67.2±0.0 °C

[ Exact Mass ]:
89.084061

[ PSA ]:
46.25000

[ LogP ]:
-0.61

[ Vapour density ]:
3 (vs air)

[ Vapour Pressure ]:
0.6±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.447

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents. May present an explosion hazard if heated.

[ Water Solubility ]:
miscible

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA5950000

CHEMICAL NAME :: 1-Propanol, 2-amino-2-methyl-

CAS REGISTRY NUMBER :: 124-68-5

BEILSTEIN REFERENCE NO. :: 0505979

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C4-H11-N-O

MOLECULAR WEIGHT :: 89.16

WISWESSER LINE NOTATION :: ZX1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 22,315,1940 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44800 mg/kg/8W-C

TOXIC EFFECTS :: Liver - other changes Skin and Appendages - hair Related to Chronic Data - death

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 230 ug/m3/4H/13W-I

TOXIC EFFECTS :: Cardiac - changes in heart weight Lungs, Thorax, or Respiration - changes in lung weight Related to Chronic Data - changes in uterine weight

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 11340 mg/kg/28D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 6 mg/m3/89D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 100 mg/m3/4H/13W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M5222 No. of Facilities: 2958 (estimated) No. of Industries: 28 No. of Occupations: 44 No. of Employees: 24640 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M5222 No. of Facilities: 16965 (estimated) No. of Industries: 136 No. of Occupations: 94 No. of Employees: 219300 (estimated) No. of Female Employees: 54846 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H412

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/38;R52/53

[ Safety Phrases ]:
S61

[ RIDADR ]:
2735

[ WGK Germany ]:
1

[ RTECS ]:
UA5950000

[ Packaging Group ]:
III

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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