EGFR-IN-9

Names

[ Name ]:
EGFR-IN-9

Biological Activity

[Description]:

EGFR-IN-9 (Compound 8) is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR (WT):7 nM (IC50)

EGFRL858R/T790M:28 nM (IC50)

[In Vitro]

EGFR-IN-9 (Compound 8) shows antiproliferative activity in HCC827 lung cancer cell line with an IC50 of 8 nM.

[References]

[1]. Coumar MS, et al. Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor leadidentification. J Med Chem. 2010 Jul 8;53(13):4980-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₄N₄O₃

[ Molecular Weight ]:
476.53

Related Compounds

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