AG 99

Names

[ Name ]:
AG 99

[Synonym ]:
3,4-dihydroxybenzalcyanoacetamide
IN1036
Tyrphostin A46
2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-
(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide
Tyrphostin AG 99
HMS3266G04
(E)-2-Cyano-3-(3,4-Dihydroxyphenyl)Prop-2-Enamide
(E)-AG 99

Biological Activity

[Description]:

(E)-AG 99 ((E)-Tyrphostin 46; (E)-Tyrphostin AG 99) is a potent EGFR inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR

[References]

[1]. Yamamoto N, et al. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J Cell Sci. 2006 Nov 15;119(Pt 22):4623-33.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
544.4±50.0 °C at 760 mmHg

[ Melting Point ]:
231 °C

[ Molecular Formula ]:
C₁₀H₈N₂O₃

[ Molecular Weight ]:
204.182

[ Flash Point ]:
283.0±30.1 °C

[ Exact Mass ]:
204.053497

[ PSA ]:
107.34000

[ LogP ]:
0.02

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.711

[ Storage condition ]:
Desiccate at +4°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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