SN-38 GLUCURONIDE

Names

[ Name ]:
SN-38 GLUCURONIDE

[Synonym ]:
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl β-D-glucopyranosiduronic acid
sn-38 glucuronide
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-9-(β-D-glucopyranuronosyloxy)-4-hydroxy-, (4S)-

Biological Activity

[Description]:

SN-38 glucuronide is an inactive metabolite of the cancer drug Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Pellock SJ, et al. Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018;293(48):18559-18573.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
1019.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₂₈N₂O₁₁

[ Molecular Weight ]:
568.529

[ Flash Point ]:
570.5±34.3 °C

[ Exact Mass ]:
568.169312

[ PSA ]:
197.87000

[ LogP ]:
-0.28

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.746

SN-38 GLUCURONIDE

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds