5'-ODMT cEt m5U Phosphoramidite (Amidite)

Names

[ CAS No. ]:
1197033-22-9

[ Name ]:
5'-ODMT cEt m5U Phosphoramidite (Amidite)

Biological Activity

[Description]:

5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity[1][2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Fiona J. Laraman, et al. Investigating the Activation Kinetics of Phosphoramidites for Oligonucleotide Synthesis. Org. Process Res. Dev. 2022, 26, 3, 764-772.

[2]. Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₂H₅₁N₄O₉P

[ Molecular Weight ]:
786.85000

[ Exact Mass ]:
786.33900

[ PSA ]:
160.35000

[ LogP ]:
6.99928

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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