Rabeprazole thioether

Names

[ Name ]:
Rabeprazole thioether

[Synonym ]:
2-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio]benzimidazole
MFCD08063845
2-({[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl}sulfanyl)-1H-benzimidazole
2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole
1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-
2-({[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfanyl)-1H-benzimidazole
2-[[[4-(3-Methoxy Propoxy)-3-methyl pyridine-2-yl]methyl ] thio]-1H-benzimidazole
2-[[[4-(3-Methoxy Propoxy)-3-methyl pyridine-2-yl ]methyl ] thio]-1H-benzimidazole
2-(((4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL)METHYL)THIO)-1H-BENZIMIDAZOLE
2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfanyl]-1H-benzimidazole

Biological Activity

[Description]:

Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H+/K+)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment[1][2].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Uno T, et al. Determination of rabeprazole and its active metabolite, rabeprazole thioether in human plasma by column-switching high-performance liquid chromatography and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):238-43.

[2]. Tsutsui N, et al. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother. 2000 Nov;44(11):3069-73.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
546.4±60.0 °C at 760 mmHg

[ Melting Point ]:
120.5-121.5ºC

[ Molecular Formula ]:
C₁₈H₂₁N₃O₂S

[ Molecular Weight ]:
343.443

[ Flash Point ]:
284.2±32.9 °C

[ Exact Mass ]:
343.135437

[ PSA ]:
85.33000

[ LogP ]:
3.53

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%