Erucic acid

Names

[ CAS No. ]:
112-86-7

[ Name ]:
Erucic acid

[Synonym ]:
13-Docosenoic acid, (13Z)-
(Z)-13-Docosenoic acid
(Z)-docos-13-enoic acid
Prifac 2990
(13Z)-13-Docosenoic acid
(13Z)-Docosenoic acid
DOCOSENOIC ACID
Prifrac 2990
Erucidic acid
MFCD00063188
brassidic acid
Erucic acid
13Z-docosenoic acid
(13Z)-Docos-13-enoic acid
13-Docosenoic acid, (Z)-
Z-13-Docosenoic acid
EINECS 204-011-3
UNII-075441GMF2
D13:14-Docosenoic Acid
cis-13-Docosenoic acid
Hystrene 2290
Erunic Acid
13-cis-docosenoic acid

Biological Activity

[Description]:

Erucic acid, a monounsaturated fatty acid (MUFA), is isolated from the seed of Raphanus sativus L. Erucic acid can readily cross the blood-brain barrier (BBB), it has been reported to normalize the accumulation of very long-chain fatty acids in the brain. Erucic acid can improve cognitive impairment and be effective against dementia[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

Research Areas >> Neurological Disease

[In Vivo]

Erucic acid (oral administration; 3 mg/kg) enhances the phosphorylation level of PI3K, PKCζ, ERK, CREB and Akt in the hippocampus compared with that in the vehicle-treated control group[1]. Animal Model: Normal naïve mice[1] Dosage: 3 mg/kg Administration: Oral administration; 3 mg/kg Result: Enhanced the phosphorylation level of PI3K, PKCζ, ERK, CREB and Akt in the hippocampus.

[References]

[1]. Kim E, et al. The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice. Pharmacol Biochem Behav. 2016 Mar;142:85-90.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
386.1±0.0 °C at 760 mmHg

[ Melting Point ]:
28-32 °C(lit.)

[ Molecular Formula ]:
C₂₂H₄₂O₂

[ Molecular Weight ]:
338.568

[ Flash Point ]:
349.9±15.2 °C

[ Exact Mass ]:
338.318481

[ PSA ]:
37.30000

[ LogP ]:
9.82

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.468

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
JR1280000

[ HS Code ]:
2916190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Genotoxicity testing of esterified propoxylated glycerol (EPG).

Regul Toxicol Pharmacol 70 Suppl 2 , S131-42, (2014)

Four versions of esterified propoxylated glycerols (EPGs) were evaluated for potential genotoxicity using a range of in vitro and in vivo assays. H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soya...

Development and application of a comparative fatty acid analysis method to investigate voriconazole-induced hepatotoxicity.

Clin. Chim. Acta 438 , 126-34, (2014)

As fatty acids play an important role in biological regulation, the profiling of fatty acid expression has been used to discover various disease markers and to understand disease mechanisms. This stud...

An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.

J. Nat. Prod. 73 , 1193-5, (2010)

Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple fo...