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Pim1/AKK1-IN-1

Names

[ CAS No. ]:
1093222-27-5

[ Name ]:
Pim1/AKK1-IN-1

[Synonym ]:
3-Pyridinecarboxamide,N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]
CS-0342
LKB1 (AAK1 dual inhibitor)
N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide
LKB1(AAK1 dual inhibitor)||3-Pyridinecarboxamide,N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]
Pim1/AKK1-IN-1

Biological Activity

[Description]:

Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> Pim
Research Areas >> Cancer

[Target]

Kd: 35 nM (Pim1), 53 nM (AKK1), 75 nM (MST2), 380 nM (LKB1)


[In Vitro]

Pim1/AKK1-IN-1 is multi-kinase inhibitor, and has Kd of 380 nM against LKB1 and 53 nM against AAK1[1].

[References]

[1]. Bamborough P, et al. Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem. 2008 Dec 25;51(24):7898-914.


[Related Small Molecules]

AZD1208 | PIM-447 dihydrochloride | SGI-1776 free base | CX-6258 | TP-3654 | Hispidulin | TCS PIM-1 1 | TCS-PIM-1-4a | GDC-0339 | SMI-16a | M-110 | INCB053914 phosphate | 3,3',4',5,6,7-HEXAHYDROXYFLAVONE

Chemical & Physical Properties

[ Density]:
1.42

[ Molecular Formula ]:
C20H13N5O

[ Molecular Weight ]:
339.35000

[ Exact Mass ]:
339.11200

[ PSA ]:
97.95000

[ LogP ]:
4.13288

[ Storage condition ]:
2-8℃

Related Compounds