PS 1145 dihydrochloride

Names

[ Name ]:
PS 1145 dihydrochloride

[Synonym ]:
N-(6-Chloro-9H-β-carbolin-8-yl)nicotinamide dihydrochloride
3-Pyridinecarboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-, hydrochloride (1:2)
PS-1145 Dihydrochloride

Biological Activity

[Description]:

PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Inflammation/Immunology

[Target]

IC50: 88 nM (IκB kinase-2)[1]

[References]

[1]. Cernackova A, et al. Cachexia induced by Yoshida ascites hepatoma in Wistar rats is not associated with inflammatory response in the spleen or brain. J Neuroimmunol. 2019;337:577068.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₃Cl₃N₄O

[ Molecular Weight ]:
395.670

[ Exact Mass ]:
394.015503

[ PSA ]:
74.16000

[ LogP ]:
6.00480

Related Compounds

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