Telomerase is a ribonucleoprotein that is an enzyme that adds DNA sequence repeats ("TTAGGG" in all vertebrates) to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. This region of repeated nucleotide called telomeres contains noncoding DNA and hinders the loss of important DNA from chromosome ends. As a result, every time the chromosome is copied, only 100–200 nucleotides are lost, which causes no damage to the organism's DNA. Telomerase is a reverse transcriptase that carries its own RNA molecule, which is used as a template when it elongates telomeres, which are shortened after each replication cycle. Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells.


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BMVC

BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities[1][2].

  • CAS Number: 627810-06-4
  • MF: C28H25I2N3
  • MW: 657.33
  • Catalog: DNA/RNA Synthesis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

360A

360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.

  • CAS Number: 794458-56-3
  • MF: C27H23N5O2
  • MW: 449.5
  • Catalog: G-quadruplex
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Telomerase-IN-2

Telomerase-IN-2 is a telomerase inhibitor, and inhibits telomerase activity by decreasing expression of dyskerin, with an IC50 of 0.89 µM. Anti-cancer activity[1].

  • CAS Number: 1610878-54-0
  • MF: C34H39N3O9
  • MW: 633.69
  • Catalog: Telomerase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Telomerase-IN-3

Telomerase-IN-3 is a telomerase inhibitor, which directly targets hTERT promoter activity. hTERT is the key component for maintenance of telomerase activity[1].

  • CAS Number: 150096-77-8
  • MF: C19H16ClN5O3
  • MW: 397.82
  • Catalog: Telomerase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

360A iodide

360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.

  • CAS Number: 737763-37-0
  • MF: C27H23I2N5O2
  • MW: 703.31
  • Catalog: G-quadruplex
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Abacavir (sulfate)

Abacavir monosulfate is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir monosulfate can inhibits the replication of HIV. Abacavir monosulfate shows anticancer activity in prostate cancer cell lines. Abacavir monosulfate can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].

  • CAS Number: 216699-07-9
  • MF: C14H20N6O5S
  • MW: 384.411
  • Catalog: HIV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Ceramides Mixture

Ceramides Mixture is an endogenous ceramide and consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides Mixture is a main lipid component of the permeability barrier in epidermis. Ceramides Mixture is involved in the regulation of growth inhibition, cell cycle arrest, and modulation of telomerase activity[1][2].

  • CAS Number: 100403-19-8
  • MF: C24H47NO3
  • MW: 397.63488
  • Catalog: Telomerase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

L2H2-6OTD

L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC50 value of 15 nM[1].

  • CAS Number: 1016263-75-4
  • MF: C30H30N10O8
  • MW: 658.62
  • Catalog: Telomerase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MST312

MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1].

  • CAS Number: 368449-04-1
  • MF: C20H16N2O6
  • MW: 380.35100
  • Catalog: Telomerase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Telomestatin

Telomestatin is a very potent telomerase inhibitor and can be isolated from Streptomyces anulatus 3533-SV4. Telomestatin selectively facilitates the formation of intramolecular G-quadruplexes, in particular, that produced from the human telomeric sequence d[T2AG3]4. Telomestatin is an ADC cytotoxin and can be used for cancer research[1].

  • CAS Number: 265114-54-3
  • MF: C26H14N8O7S
  • MW: 582.504
  • Catalog: Telomerase
  • Density: 2.0±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

abacavir sulfate

Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir hydrochloride can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].

  • CAS Number: 136777-48-5
  • MF: C28H38N12O6S
  • MW: 670.74300
  • Catalog: HIV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

7-Deaza-2′-deoxyguanosine 5′-triphosphate

7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, is a telomerase inhibitor (IC50: 11 μM)[1].

  • CAS Number: 101515-08-6
  • MF: C11H16LiN4O13P3
  • MW: 512.12600
  • Catalog: Telomerase
  • Density: 2.48 g/cm3
  • Boiling Point: 907.1ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 502.4ºC

BIBR 1532

BIBR 1532 is a potent, selective and non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay.

  • CAS Number: 321674-73-1
  • MF: C21H17NO3
  • MW: 331.365
  • Catalog: Telomerase
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 600.6±48.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 317.0±29.6 °C

Epithalon

Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa[1].

  • CAS Number: 307297-39-8
  • MF: C14H22N4O9
  • MW: 390.346
  • Catalog: Telomerase
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 959.8±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 534.3±34.3 °C

Telomerase-IN-1

Telomerase-IN-1 is a Telomerase inhibitor with an IC50 of 0.19 μM.

  • CAS Number: 666859-49-0
  • MF: C21H23FN2O4
  • MW: 386.417
  • Catalog: Telomerase
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 512.7±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 263.9±30.1 °C

5,10,15,20-Tetrakis(N-methyl-4-pyridyl)porphine tetratosylate

TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand, which inhibits the interaction between G-quadruplexes and IGF-1[1]. TMPyP4 tosylate (TMP 1363) is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines[2].

  • CAS Number: 36951-72-1
  • MF: C72H66N8O12S4
  • MW: 1363.60
  • Catalog: G-quadruplex
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A