1404-64-4

• 常用中文名：司帕索霉素
• 常用英文名：Sparsomycin
• CAS号：1404-64-4
• 分子式：C₁₃H₁₉N₃O₅S₂
• 分子量：361.44
• 发布时间：2018-07-23 19:11:06
• 更新时间：2024-01-14 18:07:09
• 稀疏霉素是稀疏链霉菌的代谢产物。Sparsomycin抑制真核细胞和细菌中的蛋白质合成。Sparsomycin抑制核糖体PTC的翻译延伸[1]。

名称

• 中文名: 司帕索霉素
• 英文名: sparsomycin
• 中文别名: 司帕霉素
• 英文别名: Sparsomycin from Streptomyces sparsogenes; sparsamycin

物化性质

• 密度: 1.466g/cm3
• 分子式: C₁₃H₁₉N₃O₅S₂
• 分子量: 361.44
• 精确质量: 361.07700
• PSA: 176.63000
• LogP: 0.18770
• 折射率: 1.656

生物活性

• 描述: 稀疏霉素是稀疏链霉菌的代谢产物。Sparsomycin抑制真核细胞和细菌中的蛋白质合成。Sparsomycin抑制核糖体PTC的翻译延伸[1]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Codjo H, et, al. COVID-19: Mechanisms of the Antiviral Activities of Selective Antibiotics Targeting the Human 80S Ribosome. 2021;15:38-52.

  [2]. Lazaro E, et, al. Interaction of the antibiotic sparsomycin with the ribosome. Antimicrob Agents Chemother. 1991 Jan;35(1):10-3.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WG5850000 CHEMICAL NAME : Sparsomycin CAS REGISTRY NUMBER : 1404-64-4 LAST UPDATED : 199504 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C13-H19-N3-O5-S2 MOLECULAR WEIGHT : 361.47 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 20 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

安全

• 危害码 (欧洲): T+: Very toxic;
• 风险声明 (欧洲): 28
• 安全声明 (欧洲): 28-36/37-45
• 危险品运输编码: UN 2811 6.1/PG 2