3443-28-5

• 常用中文名：Prudomestin
• 常用英文名：Prudomestin
• CAS号：3443-28-5
• 分子式：C₁₇H₁₄O₇
• 分子量：330.289
• 相关类别： 天然产物 黄酮类化合物
• 发布时间：2017-12-06 15:49:38
• 更新时间：2024-01-24 07:54:45
• Prudomestin,从 Prunus domestica 心材中分离得到,具有很强的黄嘌呤氧化酶 (XO) 抑制活性(IC50≈6 µM)。

名称

• 中文名: 3,5,7-三羟基-8,4'-二甲氧基黄酮
• 英文名: 3,5,7-Trihydroxy-8-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
• 英文别名: 3,5,7-Trihydroxy-8-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-8-methoxy-2-(4-methoxyphenyl)-; 3,5,7-Trihydroxy-6,8-dimethoxyflavone; 3,5,7-trihydroxy-8,4'-dimethoxyflavone; Predomestin; 3,5,7-Trihydroxy-6,8-dimethoxy-flavon; 3,5,7-Trihydroxy-8,4'-dimethoxy-flavon; Prudomestin; 3,5,7-trihydroxy-4',8-dimethoxyflavone; 3,5,7-trihydroxy-6,8-dimethoxy-2-phenyl-chromen-4-one; 4H-1-Benzopyran-4-one,3,5,7-trihydroxy-6,8-dimethoxy-2-phenyl

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 568.9±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄O₇
• 分子量: 330.289
• 闪点: 212.2±23.6 °C
• 精确质量: 330.073944
• PSA: 109.36000
• LogP: 2.01
• 外观性状: 黄色晶体
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.681
• 储存条件: 2-8℃，干燥，密闭

生物活性

• 描述: Prudomestin,从 Prunus domestica 心材中分离得到,具有很强的黄嘌呤氧化酶 (XO) 抑制活性(IC50≈6 µM)。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 代谢酶/蛋白酶 >> 黄嘌呤氧化酶
• 参考文献:

  [1]. Nooreen Z, et al. Characterization and evaluation of bioactive polyphenolic constituents from Zanthoxylum armatum DC., a traditionally used plant. Biomed Pharmacother. 2017 May;89:366-375.

  [2]. Ranjana, et al. Standardization and xanthine oxidase inhibitory potential of Zanthoxylum armatum fruits. J Ethnopharmacol. 2019 Feb 10;230:1-8.

安全

• 危害码 (欧洲): Xi
• 海关编码: 2914509090

合成路线

117155-43-8 ~77% 3443-28-5

文献：Horie; Tsukayama; Kawamura; Seno; Yamamoto Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 441-447

117155-41-6 ~85% 3443-28-5

文献：Horie; Tsukayama; Kawamura; Seno; Yamamoto Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 441-447

7736-86-9 ~% 3443-28-5

文献：Horie; Tsukayama; Kawamura; Seno; Yamamoto Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 441-447

85734-53-8 ~% 3443-28-5

文献：Horie; Tsukayama; Kawamura; Seno; Yamamoto Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 441-447

1570-09-8 ~% 3443-28-5

文献：Horie; Tsukayama; Kawamura; Seno; Yamamoto Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 441-447

95125-09-0 ~% 3443-28-5

文献：Horie; Tsukayama; Kawamura; Seno; Yamamoto Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 441-447

117155-42-7 ~% 3443-28-5

文献：Horie; Tsukayama; Kawamura; Seno; Yamamoto Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 441-447

117155-40-5 ~% 3443-28-5

文献：Horie; Tsukayama; Kawamura; Seno; Yamamoto Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 441-447

上下游产品

上游产品  3
7736-86-9 85734-53-8 1570-09-8
下游产品  0

海关

海关编码	2914509090
中文概述	2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙酮报明包装
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%