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α-Helical CRF (9-41)

α-Helical CRF (9-41)用途

α-螺旋促肾上腺皮质激素释放因子(9-41)是一种促肾上腺皮质素释放因子(CRF)拮抗剂。α-螺旋促肾上腺皮质激素释放因子(9-41)降低体内血浆生长激素(GH)值[1][2]。

α-Helical CRF (9-41)名称

[ CAS 号 ]:
99658-03-4

[ 中文名 ]:
肾上腺皮质素释放因子拮抗剂

[ 英文名 ]:
α-Helical CRF (9-41) trifluoroacetate salt

[英文别名 ]:

MFCD00081543

α-Helical CRF (9-41)生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> CRFR

研究领域 >> 炎症/免疫

[体内研究]

α-螺旋促肾上腺皮质激素释放因子(9-41)(10μg；大脑第三或侧脑室注射；一次)显著降低血浆GH值[1]。α-螺旋促肾上腺皮质激素释放因子(9-41)(100 ng/kg；静脉注射一次)影响rhlL-1/β诱导的脾交感神经活性增强[2]。动物模型：成年Sprague-Dawley大鼠[1]剂量：10μg给药：第三脑室或侧脑室注射；10μg一次结果：在暴露于压力前45分钟,通过向大脑的第三或侧脑室注射,消除10分钟电击导致血浆GH水平下降。动物模型：免疫内源性生长抑素(SS)的成年Sprague-Dawley大鼠[1]剂量：10μg给药：侧脑室注射；10μg一次结果：内源性SS被免疫中和的大鼠对血浆GH值没有影响,但干扰了GH释放因子(GRF)的刺激作用。动物模型：注射rhlL-1/β的雄性Wistar大鼠[2]剂量：100 ng/kg给药：脑室注射；结果：完全阻断rhlL-1/β诱导的脾交感神经活性增强,但不能改变rhlL-1β引起的伤害性行为增强。

[参考文献]

[1]. Rivier C, Vale W. Involvement of corticotropin-releasing factor and somatostatin in stress-induced inhibition of growth hormone secretion in the rat. Endocrinology. 1985 Dec;117(6):2478-82.

[2]. Takakazu Oka, et al. Intracerebroventricular injection of interleukin-1/β induces hyperalgesia in rats. Brain Research, 624 (1993) 61-68.

α-Helical CRF (9-41)物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
717.1±60.0 °C at 760 mmHg

[ 分子式 ]:
C₁₆₆H₂₇₄N₄₆O₅₃S₂

[ 分子量 ]:
3826.36

[ 闪点 ]:
387.5±32.9 °C

[ 精确质量 ]:
540.075745

[ LogP ]:
3.33

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.602

α-Helical CRF (9-41)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

α-Helical CRF (9-41)文献

Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats.

Int. J. Endocrinol. 2010 , 326151, (2010)

Studies have shown that sleep recovery following different protocols of forced waking varies according to the level of stress inherent to each method. Sleep deprivation activates the hypothalamic-pitu...

Play fighting and corticotropin-releasing hormone in the lateral septum of golden hamsters.

Neuroscience 169 , 236-45, (2010)

This study was focused on determining the possible role of corticotropin-releasing hormone (CRH) on play fighting in juvenile golden hamsters. As no specific neural sites have been proposed, we looked...

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