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羧基酰胺

羧基酰胺用途

Carboxyamidotriazole (L 651582; CAI) 是一种非电压依赖性钙通道阻滞剂,也是一种无细胞毒性的抗肿瘤药物,并具有抗炎活性。

羧基酰胺名称

[ CAS 号 ]:
99519-84-3

[ 中文名 ]:
5-氨基-1-(3,5-二氯-4-(4-氯苯甲酰基)苄基)-1H-1,2,3-三氮唑-4-甲酰胺

[ 英文名 ]:
L-651,582

[中文别名 ]:

羧基酰胺

[英文别名 ]:

4-CAI
CAI
Carboxyamido-triazole
Carboxyamidotriazole

羧基酰胺生物活性

[ 描述 ]:

Carboxyamidotriazole (L 651582; CAI) 是一种非电压依赖性钙通道阻滞剂,也是一种无细胞毒性的抗肿瘤药物,并具有抗炎活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[ 靶点 ]

Calcium channel[1]

[参考文献]

[1]. Chen C, et al. Carboxyamidotriazole Synergizes with Sorafenib to Combat Non-Small Cell Lung Cancer through Inhibition of NANOG and Aggravation of Apoptosis. J Pharmacol Exp Ther. 2017 Aug;362(2):219-229.

[2]. Hussain MM, et al. J Clin Oncol. 2003 Dec 1;21(23):4356-63.

羧基酰胺物理化学性质

[ 密度 ]:
1.65g/cm3

[ 沸点 ]:
685.5ºC at 760 mmHg

[ 分子式 ]:
C₁₇H₁₂Cl₃N₅O₂

[ 分子量 ]:
424.67

[ 闪点 ]:
368.3ºC

[ 精确质量 ]:
423.00600

[ PSA ]:
116.89000

[ LogP ]:
4.48020

[ 外观性状 ]:
固体

[ 折射率 ]:
1.73

[ 储存条件 ]:
2-8°C，密封，干燥

羧基酰胺MSDS

羧基酰胺安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
T+

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

羧基酰胺合成路线

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羧基酰胺文献

Comparison of the applicability of mass spectrometer ion sources using a polarity- molecular weight scattergram with a 600 sample in-house chemical library.

Eur. J. Mass Spectrom. (Chichester, Eng.) 21 , 91-6, (2015)

To provide a practical guideline for the selection of a mass spectrometer ion source, we compared the applicability of three types of ion source: direct analysis in real time (DART), electrospray ioni...

Differentially expressed and activated proteins associated with non small cell lung cancer tissues.

Respir. Res. 16 , 74, (2015)

Lung cancer is a leading cause of mortality. The most common cancer subtype, non small cell lung cancer (NSCLC), accounts for 85-90% all cases and is mainly caused by environmental and genetic factors...

Intergenerational cultural conflict, mental health, and educational outcomes among Asian and Latino/a Americans: Qualitative and meta-analytic review.

Psychol. Bull. 141(2) , 404-46, (2015)

Among immigrant Asian and Latino groups, the contrast between collectivism in traditional heritage and individualism in the mainstream American cultures presents unique challenges for their family rel...

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