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水杨醛肟

水杨醛肟用途

水杨醛肟是一种有机化合物,已被用作重量法测定和分离铜、镍、钯、铅、铋和锌的试剂。水杨醛肟的铜配合物具有抗癌活性[1][2]。

水杨醛肟名称

[ CAS 号 ]:
94-67-7

[ 中文名 ]:
水杨醛肟

[ 英文名 ]:
salicylaldehyde, oxime

[中文别名 ]:

[英文别名 ]:

2-hydroxybenzaldehyde oxime
salicylaldehyde, oxime
Saldox
Benzaldehyde, 2-hydroxy-, oxime
SALICYLALDEHYDE OXIME
Salicylaldehydoxime
2-hydroxybenzaldoxime
SalicyladoximeGr
o-Hydroxybenzaldoxime
MFCD00002120

水杨醛肟生物活性

[ 描述 ]:

水杨醛肟是一种有机化合物,已被用作重量法测定和分离铜、镍、钯、铅、铋和锌的试剂。水杨醛肟的铜配合物具有抗癌活性[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

水杨醛肟(300μM)在与铜形成络合物时完全抑制拓扑异构酶II的松弛活性；还抑制L1210白血病细胞增殖[1]。

[参考文献]

[1]. W Ligett and L Biefeld. Separation and Determination of Lead with Salicylaldoxime. Ind. Eng. Chem. Anal. Ed. 1941, 13, 11, 813-815.

[2]. D. Jayaraju and Anand K. Kondapi. Anti-cancer copper salicylaldoxime complex inhibits topoisomerase II catalytic activity. Current Science. Vol. 81, No. 7 (10 October 2001), pp. 787-792

水杨醛肟物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
256.5±23.0 °C at 760 mmHg

[ 熔点 ]:
59-61 °C(lit.)

[ 分子式 ]:
C₇H₇NO₂

[ 分子量 ]:
137.136

[ 闪点 ]:
146.9±11.9 °C

[ 精确质量 ]:
137.047684

[ PSA ]:
52.82000

[ LogP ]:
1.88

[ 外观性状 ]:
白色至灰白色晶体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
2-8°C

水杨醛肟MSDS

水杨醛肟毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN5775000

CHEMICAL NAME :: Salicylaldehyde, oxime

CAS REGISTRY NUMBER :: 94-67-7

BEILSTEIN REFERENCE NO. :: 1859881

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H7-N-O2

MOLECULAR WEIGHT :: 137.15

WISWESSER LINE NOTATION :: QNU1R BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,36,1953

水杨醛肟安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VN5775000

水杨醛肟合成路线

水杨醛肟上下游产品

水杨醛肟上游产品

水杨醛肟下游产品

水杨醛肟制备

1.将水杨醛溶于氢氧化钠溶液中，加入盐酸羟胺。将混合物在水浴上加热半小时，用冰乙酸调至中性。冰浴冷却，析出水杨醛肟。经苯重结晶，再用含少量苯的石油醚重结晶，即得成品。

水杨醛肟文献

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

Eur. J. Med. Chem. 46 , 2453-62, (2011)

In a continuing effort to improve the subtype selectivity and agonist potency of estrogen receptor β (ERβ) ligands, we have designed and developed a thus far unexplored structural series obtained by m...

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta.

J. Med. Chem. 52 , 858-67, (2009)

The bioisosteric replacement of the phenol ring, a signature functional group of most estrogen receptor (ER) ligands, with a hydrogen-bonded pseudocyclic ring, led to the development of a novel class ...

Linking [M(III)3] triangles with "double-headed" phenolic oximes.

Dalton Trans. 41(29) , 8777-85, (2012)

Strapping two salicylaldoxime units together with aliphatic α,Ω-aminomethyl links in the 3-position gives ligands which allow the assembly of the polynuclear complexes [Fe(7)O(2)(OH)(6)(H(2)L1)(3)(py)...

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