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盐酸Zatebradine

盐酸Zatebradine用途

Zatebradine(UL-FS49)盐酸盐是HCN离子通道高效拮抗剂,可逆性降低心率,10uM浓度可抑制hHCN1达92%。

盐酸Zatebradine名称

[ CAS 号 ]:
91940-87-3

[ 中文名 ]:
3-[3-[[2-(3,4-二甲氧基苯基)乙基]甲基氨基]丙基]-1,3,4,5-四氢-7,8-二甲氧基-2H-3-苯并氮杂-2-酮盐酸盐

[ 英文名 ]:
Zatebradine hydrochloride

[英文别名 ]:

Zatebradine dihydrochloride
Zatebradine hydrochloride
UL-FS49
Zatebradine (hydrochloride)

盐酸Zatebradine生物活性

[ 描述 ]:

Zatebradine(UL-FS49)盐酸盐是HCN离子通道高效拮抗剂,可逆性降低心率,10uM浓度可抑制hHCN1达92%。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> HCN频道

研究领域 >> 心血管疾病

[参考文献]

[1]. Gill CH, et al. Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol. 2004 Oct;143(3):411-21.

[2]. Van Bogaert PP, et al. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.

[3]. Matt L, et al. HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path. Cell Mol Life Sci. 2011 Jan;68(1):125-37.

[相关活性小分子]

N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐 | 扎替雷定 | 西洛雷定盐酸盐

盐酸Zatebradine物理化学性质

[ 密度 ]:
1.115g/cm3

[ 沸点 ]:
612.5ºC at 760mmHg

[ 分子式 ]:
C₂₆H₃₇ClN₂O₅

[ 分子量 ]:
493.03500

[ 闪点 ]:
324.3ºC

[ 精确质量 ]:
492.23900

[ PSA ]:
60.47000

[ LogP ]:
3.95270

[ 储存条件 ]:
-20°C，密闭，干燥

盐酸ZatebradineMSDS

详细MSDS(安全技术说明书)

盐酸Zatebradine安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

盐酸Zatebradine文献

Abnormal diastolic currents in ventricular myocytes from spontaneous hypertensive heart failure rats.

Am. J. Physiol. Heart Circ. Physiol. 291(5) , H2192-8, (2006)

Hypertension is a common cause of heart failure, and ventricular arrhythmias are a major cause of death in heart failure. The spontaneous hypertension heart failure (SHHF) rat model was used to study ...

Effects of tachycardia on regional wall motion in acute ischemic canine heart.

Tohoku J. Exp. Med. 203(2) , 111-21, (2004)

Tachycardia accompanies the preload reduction. Our aim is to assess the effect of the heart rate change on wall motion in ischemic heart. In 8 dogs with occlusion of left anterior descending artery, w...

Validation of a high-sensitivity assay for zatebradine in dried blood spots of human blood at pg/ml concentrations using HILIC-MS/MS.

Bioanalysis 2(11) , 1863-71, (2010)

One of the main reasons for the increased popularity of dried blood spots (DBS) is related to the 3Rs principles (replacement, refinement and reduction) for animal use in drug development. The small b...

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