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腺苷脱氨酶(ADA),来源于微生物重组蛋白

腺苷脱氨酶(ADA),来源于微生物重组蛋白用途

Adenosine deaminase 是一种酶,可以对腺苷和 2'-脱氧腺苷进行不可逆的脱氨基作用,分别转化为肌苷和 2'-脱氧肌苷。

腺苷脱氨酶(ADA),来源于微生物重组蛋白名称

[ CAS 号 ]:
9026-93-1

[ 中文名 ]:
腺苷脱氨酶

[ 英文名 ]:
Native Calf Adenosine Deaminase

[中文别名 ]:

[英文别名 ]:

adenosine deaminase type viii
adenosine deaminase type ix
MFCD00081287
human adenosine deaminase
adenosine deaminase
adenosine deaminase, bovine intestine
ec 3.5.4.4
adenosine deaminase type v
Native Calf Adenosine Deaminase

腺苷脱氨酶(ADA),来源于微生物重组蛋白生物活性

[ 描述 ]:

Adenosine deaminase 是一种酶,可以对腺苷和 2'-脱氧腺苷进行不可逆的脱氨基作用,分别转化为肌苷和 2'-脱氧肌苷。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 腺苷脱氨酶

研究领域 >> 炎症/免疫

[体外研究]

腺苷脱氨酶(ADA; EC 3.5.4.4)分别催化腺苷和2'-脱氧腺苷对肌苷和2'-脱氧肌苷的不可逆脱氨作用。腺苷脱氨酶与嘌呤代谢有关,并分布在大多数哺乳动物组织中。遗传性腺苷脱氨酶缺乏通过减少淋巴样细胞的分化和成熟而导致淋巴细胞减少和严重的联合免疫缺陷病[1]。腺苷脱氨酶是一种与T淋巴细胞活化相关的信号分子,使其成为一种有用的炎症标志物,特别是对于脑膜炎和结核性胸膜炎[2]。

[参考文献]

[1]. Tian X, et al. Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations. PLoS One. 2018 Nov 16;13(11):e0207234.

[2]. Silva Dalsasso Joaquim L, et al. Analytical validation of an in-house method for adenosine deaminase determination. J Clin Lab Anal. 2018 Nov 29:e22823.

[相关活性小分子]

喷司他丁 | AMPD2抑制剂1

腺苷脱氨酶(ADA),来源于微生物重组蛋白物理化学性质

[ 储存条件 ]:
2-8C

腺苷脱氨酶(ADA),来源于微生物重组蛋白安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危险品运输编码 ]:
NONH for all modes of transport

腺苷脱氨酶(ADA),来源于微生物重组蛋白文献

Ecto-5'-nucleotidase, CD73, is an endothelium-derived hyperpolarizing factor synthase.

Arterioscler. Thromb. Vasc. Biol. 33(3) , 629-36, (2013)

Adenosine dilates human coronary arteries by activating potassium channels in an endothelial cell-independent manner. Cell surface ecto-5'-nucleotidase (CD73) rapidly dephosphorylates extracellular ad...

Ectoenzymes and cholinesterase activity and biomarkers of oxidative stress in patients with lung cancer.

Mol. Cell Biochem. 374(1-2) , 137-48, (2013)

We aimed to examine the nucleoside triphosphate diphosphohydrolases (NTPDase) in lymphocytes; adenosine deaminase (ADA) and butyrylcholinesterase (BChE) in serum; and acetylcholinesterase (AChE), supe...

Acute effect of β-sitosterol on calcium uptake mediates anti-inflammatory effect in murine activated neutrophils.

J. Pharm. Pharmacol. 65(1) , 115-22, (2013)

To evaluate the effect of β-sitosterol on ⁴⁵Ca²⁺ uptake in activated murine neutrophils, and upon myeloperoxidase and adenosine deaminase activity, and interleukin-1β (IL-1β) and tumour necrosis facto...

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