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丙酮酸激酶

丙酮酸激酶用途

1.用于生化研究，临床上常用作诊断酶，用于测定腺苷二磷酸(ADP)、腺苷一磷酸(AMP)、磷酸烯醇丙酮酸盐和磷酸甘油酸盐。

2.常用诊断用酶。生物化学反应和酶的分析。定量测定磷酸烯醇丙酮酸（PEP）、ADP、血糖、甘油三酯等及一些酶的催化转磷作用。

丙酮酸激酶名称

[ CAS 号 ]:
9001-59-6

[ 中文名 ]:
丙酮酸激酶

[ 英文名 ]:
Pyruvate kinase

[英文别名 ]:

Histidine, β-alanyl-
b-Alanylhistidine
β-Alanylhistidine
carnosine
N-(3-Aminopropanoyl)histidine
MFCD00081946
EINECS 232-616-2

丙酮酸激酶生物活性

[ 描述 ]:

丙酮酸激酶是一种糖酵解酶,催化磷酸烯醇式丙酮酸和ADP转化为丙酮酸和ATP[1]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. Israelsen WJ, et al. Pyruvate kinase: Function, regulation and role in cancer. Semin Cell Dev Biol. 2015 Jul;43:43-51.

丙酮酸激酶物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
656.2±55.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₁₄N₄O₃

[ 分子量 ]:
226.232

[ 闪点 ]:
350.7±31.5 °C

[ 精确质量 ]:
226.106583

[ LogP ]:
-2.17

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
2-8°C

丙酮酸激酶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

丙酮酸激酶制备

以兔肌为原料，匀浆、水抽提后，分别用硫酸铵和乙醇分级沉淀，加热除去无活性蛋白后，再次用硫酸铵沉淀，重结晶后精制而得。

丙酮酸激酶文献

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal. 2 , ra46, (2009)

Protein phosphorylation events during T cell receptor (TCR) signaling control the formation of complexes among proteins proximal to the TCR, the activation of kinase cascades, and the activation of tr...

Initial characterization of the human central proteome.

BMC Syst. Biol. 5 , 17, (2011)

On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitous...

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

Cell 127(3) , 635-648, (2006)

Cell signaling mechanisms often transmit information via posttranslational protein modifications, most importantly reversible protein phosphorylation. Here we develop and apply a general mass spectrom...

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