<生产厂家价格>

醋氯芬酸

醋氯芬酸用途

Aceclofenac是非甾体抗炎化合物Diclofenac类似物。

醋氯芬酸名称

[ CAS 号 ]:
89796-99-6

[ 中文名 ]:
醋氯芬酸

[ 英文名 ]:
Aceclofenac

[中文别名 ]:

2-[(2,6-二氯苯基)氨基]苯乙酰氧基乙酸

[英文别名 ]:

Acelofenac
Aceclofenac
EINECS 205-783-4
Aceclofar
Preservex
MFCD00864296
Falcol
Tresquim
Biofenac
Zerodol

醋氯芬酸生物活性

[ 描述 ]:

Aceclofenac是非甾体抗炎化合物Diclofenac类似物。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

COX-2:3 μM (IC50)

COX-1:7.3 μM (IC50)

[参考文献]

[1]. Dannhardt G, et al. In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs). Inflamm Res. 2001 May;50(5):262-9.

[相关活性小分子]

醋氯芬酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
486.0±45.0 °C at 760 mmHg

[ 熔点 ]:
149-153°C

[ 分子式 ]:
C₁₆H₁₃Cl₂NO₄

[ 分子量 ]:
354.185

[ 闪点 ]:
247.8±28.7 °C

[ 精确质量 ]:
353.022156

[ PSA ]:
75.63000

[ LogP ]:
4.16

[ 外观性状 ]:
白色或灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.639

[ 储存条件 ]:
-20°C Freezer

醋氯芬酸MSDS

醋氯芬酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1577900

CHEMICAL NAME :: Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-, carboxymethyl ester

CAS REGISTRY NUMBER :: 89796-99-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H13-Cl2-N-O4

MOLECULAR WEIGHT :: 354.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 41,1265,1991

醋氯芬酸安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H319-H410

[ 警示性声明 ]:
P273-P301 + P310-P305 + P351 + P338-P501

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
2811.0

[ WGK德国 ]:
3

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2922509090

醋氯芬酸合成路线

醋氯芬酸上下游产品

醋氯芬酸上游产品

醋氯芬酸下游产品

醋氯芬酸制备

1.下列化合物和溴乙酸苄酯反应，生成物催化氢化得到醋氯芬酸。

2.2-(2,6-二氯苯氨基) 苯乙酰氧基乙酸叔丁酯的制备

在反应瓶中加入乙腈120ml和双氯芬酸钠19.2g(0.06mol),搅拌加热至回流,滴加氯乙酸叔丁酯10.8g(0.07mol),滴毕搅拌回流24h(TLC跟踪).反应毕,抽滤,滤液蒸除溶剂,得淡黄色油状物2-(2,6-二氯苯氨基) 苯乙酰氧基乙酸叔丁酯22.8g, 直接用于下步反应.

3. 醋氯芬酸的合成

在反应瓶中加入2-(2,6-二氯苯氨基) 苯乙酰氧基乙酸叔丁酯上步一批得量、甲苯20ml和浓盐酸5ml,拌加热至60 ºC, 待2-(2,6-二氯苯氨基) 苯乙酰氧基乙酸叔丁酯全溶后于55~60ºC下搅拌1.5h.反应毕,冷至室温,析出大量白色晶体.抽滤,滤饼用水反复洗涤,抽干,干燥,用甲醇重结晶,得白色粉末状固体醋氯芬酸17.4g,两步收率82%,mp144~146ºC.

醋氯芬酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

醋氯芬酸文献

Development and implication of methodology for aceclofenac in pure and pharmaceutical formulations by microwave assisted spectrophotometry.

Pak. J. Pharm. Sci. 26(1) , 169-73, (2013)

A simple, fast and cost effective method for determination of aceclofenac in pure and tablet formulations has been developed and validated. The method is based on formation of stable blue coloured com...

Electrospun zein/eudragit nanofibers based dual drug delivery system for the simultaneous delivery of aceclofenac and pantoprazole.

Int. J. Pharm. 438(1-2) , 117-22, (2012)

Electrospun composite zein/eudragit nanofibers were developed with an aim to deliver two different classes of drugs simultaneously that would restrict/compensate the adverse effects of non-steroidal a...

Absolute bioavailability and metabolism of aceclofenac in rats.

Arch. Pharm. Res. 38(1) , 68-72, (2015)

Aceclofenac is one of the most popular analgesic and anti-inflammatory drugs used for the relief of pain, rheumatoid arthritis, and osteoarthritis. To date, no intravenous preparation of aceclofenac h...

更多文献