<生产厂家价格>

吡啶-2,3-二羧酸

吡啶-2,3-二羧酸用途

Quinolinic acid 是一种内源性的 N-甲基-D-天冬氨酸受体激动剂,通过犬尿氨酸途径从 L-色氨酸合成,因此具有调节 N-甲基-D-天冬氨酸神经元损伤和功能障碍的潜力。

吡啶-2,3-二羧酸名称

[ CAS 号 ]:
89-00-9

[ 中文名 ]:
喹啉酸

[ 英文名 ]:
Quinolinic acid

[中文别名 ]:

[英文别名 ]:

2,3-Pyridinedicarboxylic acid
MFCD00006295
EINECS 201-874-8
Quinolinic acid
UNII-F6F0HK1URN
T6NJ BVQ CVQ
Pyridine-2,3-dicarboxylic acid

吡啶-2,3-二羧酸生物活性

[ 描述 ]:

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 ( Pt 5):1249-73.

[相关活性小分子]

吡啶-2,3-二羧酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
425.0±30.0 °C at 760 mmHg

[ 熔点 ]:
188-190ºC

[ 分子式 ]:
C₇H₅NO₄

[ 分子量 ]:
167.119

[ 闪点 ]:
210.9±24.6 °C

[ 精确质量 ]:
167.021851

[ PSA ]:
87.49000

[ LogP ]:
-1.44

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.628

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
0.55 g/100 mL

吡啶-2,3-二羧酸MSDS

吡啶-2,3-二羧酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7967250

CHEMICAL NAME :: 2,3-Pyridinedicarboxylic acid

CAS REGISTRY NUMBER :: 89-00-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H5-N-O4

MOLECULAR WEIGHT :: 167.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1050 mg/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992- Volume(issue)/page/year: 46,323,1994

吡啶-2,3-二羧酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
US7967250

[ 海关编码 ]:
29333999

吡啶-2,3-二羧酸合成路线

吡啶-2,3-二羧酸上下游产品

吡啶-2,3-二羧酸上游产品

吡啶-2,3-二羧酸下游产品

吡啶-2,3-二羧酸制备

用喹啉以硝酸氧化制得。

吡啶-2,3-二羧酸海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吡啶-2,3-二羧酸文献

The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.

Cell Death Differ. 22 , 1618-29, (2015)

The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain. In particular, the C...

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.

J. Neuroinflammation 12 , 110, (2015)

During inflammation, the kynurenine pathway (KP) metabolises the essential amino acid tryptophan (TRP) potentially contributing to excitotoxicity via the release of quinolinic acid (QUIN) and 3-hydrox...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

更多文献