硒(甲基)硒代半胱氨酸盐酸盐

硒(甲基)硒代半胱氨酸盐酸盐用途

Se-Methylselenocysteine hydrochloride,甲基硒的前体,具有强大的癌症化学预防活性和抗氧化活性。Se-Methylselenocysteine hydrochloride 具有口服生物活性,可诱导细胞凋亡 (apoptosis)。

硒(甲基)硒代半胱氨酸盐酸盐名称

[ CAS 号 ]:
863394-07-4

[ 中文名 ]:
Se-(甲基)硒代半胱氨酸盐酸盐

[ 英文名 ]:
3-(Methylselanyl)-L-alanine hydrochloride (1:1)

[英文别名 ]:

Se-MSC
M 6680
L-Alanine, 3-(methylseleno)-, hydrochloride (1:1)
3-(Methylselanyl)-L-alanine hydrochloride (1:1)

硒(甲基)硒代半胱氨酸盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 神经信号通路 >> β-分泌

[参考文献]

[1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92.

[2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43.

[3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107.

硒(甲基)硒代半胱氨酸盐酸盐物理化学性质

[ 分子式 ]:
C₄H₁₀ClNO₂Se

[ 分子量 ]:
218.54

[ 精确质量 ]:
218.956528

[ PSA ]:
63.32000

[ LogP ]:
1.07120

[ 外观性状 ]:
固体

[ 储存条件 ]:
20°C

硒(甲基)硒代半胱氨酸盐酸盐MSDS

详细MSDS(安全技术说明书)

硒(甲基)硒代半胱氨酸盐酸盐安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H331-H373-H410

[ 警示性声明 ]:
P261-P273-P301 + P310-P311-P501

[ 危害码 (欧洲) ]:
T

[ 危险品运输编码 ]:
UN 3283 6.1 / PGII

[ 海关编码 ]:
2922499990

硒(甲基)硒代半胱氨酸盐酸盐海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

硒(甲基)硒代半胱氨酸盐酸盐文献

Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms.

Metallomics 8 , 305-12, (2016)

Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been ...

Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells.

Mol. Cell Biochem. 327 , 111-26, (2009)

Plasma glutathione peroxidase (GPx-3) is a selenocysteine-containing extracellular antioxidant protein that catalyzes the reduction of hydrogen peroxide and lipid hydroperoxides. Selenoprotein express...

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