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菲

菲用途

Phenanthrene 是一种多环芳烃 (PAH),经常被用作监测 PAH 污染基质的指标。Phenanthrene 可以诱导氧化应激和炎症。

菲名称

[ CAS 号 ]:
85-01-8

[ 中文名 ]:
菲

[ 英文名 ]:
Phenanthrene

[中文别名 ]:

1,2-苯并萘

[英文别名 ]:

Phenanthrin
Phenanthrene
PHENANTHRENE, REAGENT
Ravatite
EINECS 201-581-5
O-DIPHENYLENEETHYLENE
Phenanthren
PHENANTHRINE
Phenanthracene
PHENANTHRENE FOR SYNTHESIS

菲生物活性

[ 描述 ]:

Phenanthrene 是一种多环芳烃 (PAH),经常被用作监测 PAH 污染基质的指标。Phenanthrene 可以诱导氧化应激和炎症。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Sun K, et al. Subcellular distribution and biotransformation of phenanthrene in pakchoi after inoculation with endophytic Pseudomonas sp. as probed using HRMS coupled with isotope-labeling. Environ Pollut. 2018 Jun;237:858-867.

[2]. Dupuy J, et al. Effect and localization of phenanthrene in maize roots. Chemosphere. 2016 Apr;149:130-6.

菲物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
337.4±9.0 °C at 760 mmHg

[ 熔点 ]:
98-100 °C(lit.)

[ 分子式 ]:
C₁₄H₁₀

[ 分子量 ]:
178.229

[ 闪点 ]:
146.6±12.8 °C

[ 精确质量 ]:
178.078247

[ LogP ]:
4.68

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.715

[ 储存条件 ]:
APPROX 4°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
insoluble

菲MSDS

详细MSDS(安全技术说明书)

菲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF7175000

CHEMICAL NAME :: Phenanthrene

CAS REGISTRY NUMBER :: 85-01-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 44

MOLECULAR FORMULA :: C14-H10

MOLECULAR WEIGHT :: 178.24

WISWESSER LINE NOTATION :: L B666J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6370 mg/kg/13W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 71 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 gm/kg/10W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 10 umol/L

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 58,1635,1977 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,419,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,419,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4032 No. of Facilities: 134 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2242 (estimated)

菲安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335-H410

[ 警示性声明 ]:
P261-P273-P305 + P351 + P338-P501

[ 靶器官 ]:
Blood, Central nervous system, Liver

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R40;R50/53

[ 安全声明 (欧洲) ]:
S26-S60-S61-S36/37-S29-S62-S45-S16-S7-S24/25-S23-S53

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
SF7175000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2902909090

菲上下游产品

菲上游产品

菲下游产品

菲制备

1.菲是煤焦油中含量较多的组分，约占煤焦油的5%，仅次于萘含量。煤焦油300-360℃馏程范围的一蒽油中，含量最多为菲，其次是蒽和咔唑等。菲的提取方法通常是把一蒽油冷却、结晶，再用真空吸滤或离心过滤分离除去油分。油分中溶有较多的菲可用精密蒸馏法回收。所得的结晶称为粗蒽，其中含蒽25-30%、咔唑22-25%、菲30%左右。粗蒽用重苯萃取、冷却、过滤，滤液蒸去溶剂后进行重结晶、过滤。取滤液精馏，即得工业菲，经磺化结晶可得精菲。

2. 烟草：OR，57。合成：用戊烷萃取。

3. 也可用邻硝基苯甲醛与苯乙酸合成。

菲海关

[ 海关编码 ]: 2902909090

[ 中文概述 ]:
2902909090. 其他芳香烃. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:2.0%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

菲文献

Electrochemical polymerization of pyrene derivatives on functionalized carbon nanotubes for pseudocapacitive electrodes.

Nat. Commun. 6 , 7040, (2015)

Electrochemical energy-storage devices have the potential to be clean and efficient, but their current cost and performance limit their use in numerous transportation and stationary applications. Many...

High-Sensitivity Surface-Enhanced Raman Scattering (SERS) Substrate Based on a Gold Colloid Solution with a pH Change for Detection of Trace-Level Polycyclic Aromatic Hydrocarbons in Aqueous Solution.

Appl. Spectrosc. 69 , 574-9, (2015)

In this study, a gold colloid solution whose parameters were optimized, and without any surfactants, was developed as a surface-enhanced Raman scattering (SERS) substrate for the detection of trace-le...

L-cysteine-capped core/shell/shell quantum dot-graphene oxide nanocomposite fluorescence probe for polycyclic aromatic hydrocarbon detection.

Talanta 146 , 780-8, (2015)

Environmental pollutants, such as the polycyclic aromatic hydrocarbons (PAHs), become widely distributed in the environment after emission from a range of sources, and they have potential biological e...

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菲

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菲名称