阿布妥因

阿布妥因用途

沙丁胺素(BAX 422Z)是一种抗惊厥剂,是一种用于研究癫痫大发作的硫海因衍生物[1]。

阿布妥因名称

[ CAS 号 ]:
830-89-7

[ 中文名 ]:
阿布妥因

[ 英文名 ]:
Albutoin

[英文别名 ]:

阿布妥因生物活性

[ 描述 ]:

沙丁胺素(BAX 422Z)是一种抗惊厥剂,是一种用于研究癫痫大发作的硫海因衍生物[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 神经疾病

[参考文献]

[1]. Herdson PB, et al. Electron microscope studies on enzyme activity and the isolation of thiohydantoin-induced myelin figures in rat liver. J Cell Biol. 1965;25(3):485-493.

[2]. Millichap JG, et al. Albutoin, a new thiohydantoin derivative for grand mal epilepsies. Comparison with diphenylhydantoin in a double-blind, controlled study. Neurology. 1967;17(2):162-165.

阿布妥因物理化学性质

[ 密度 ]:
1.12g/cm3

[ 沸点 ]:
275.2ºC at 760 mmHg

[ 分子式 ]:
C10H16N2OS

[ 分子量 ]:
212.31200

[ 闪点 ]:
120.3ºC

[ 精确质量 ]:
212.09800

[ PSA ]:
71.47000

[ LogP ]:
1.08860

[ 折射率 ]:
1.558

阿布妥因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ0775300
CHEMICAL NAME :
4-Imidazolidinone, 5-(2-methylpropyl)-3-(2-propenyl)-2-thioxo-
CAS REGISTRY NUMBER :
830-89-7
BEILSTEIN REFERENCE NO. :
0163719
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H16-N2-O-S
MOLECULAR WEIGHT :
212.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
785 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,107,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
294 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,107,1961 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg/10D-I
TOXIC EFFECTS :
Endocrine - evidence of thyroid hypofunction Endocrine - changes in thyroid weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,107,1961
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10200 mg/kg/17D-I
TOXIC EFFECTS :
Behavioral - tolerance
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,107,1961

阿布妥因安全信息

[ 海关编码 ]:
2933990090

阿布妥因合成路线

详细合成路线

阿布妥因海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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