830-89-7

• 常用中文名：阿布妥因
• 常用英文名：Albutoin
• CAS号：830-89-7
• 分子式：C₁₀H₁₆N₂OS
• 分子量：212.31200
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-02-21 08:00:00
• 更新时间：2025-08-26 12:35:56
• 沙丁胺素(BAX 422Z)是一种抗惊厥剂,是一种用于研究癫痫大发作的硫海因衍生物[1]。

名称

• 中文名: 阿布妥因
• 英文名: 5-(2-methylpropyl)-3-prop-2-enyl-2-sulfanylideneimidazolidin-4-one
• 英文别名: 3-Allyl-5-isobutyl-2-thiohydantoin; BAX 422 Z; Euprax; 3-allyl-5-isobutyl-2-thioxo-imidazolidin-4-one; ALBUTOIN; Coord

物化性质

• 密度: 1.12g/cm3
• 沸点: 275.2ºC at 760 mmHg
• 分子式: C₁₀H₁₆N₂OS
• 分子量: 212.31200
• 闪点: 120.3ºC
• 精确质量: 212.09800
• PSA: 71.47000
• LogP: 1.08860
• 折射率: 1.558

生物活性

• 描述: 沙丁胺素(BAX 422Z)是一种抗惊厥剂,是一种用于研究癫痫大发作的硫海因衍生物[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Herdson PB, et al. Electron microscope studies on enzyme activity and the isolation of thiohydantoin-induced myelin figures in rat liver. J Cell Biol. 1965;25(3):485-493.

  [2]. Millichap JG, et al. Albutoin, a new thiohydantoin derivative for grand mal epilepsies. Comparison with diphenylhydantoin in a double-blind, controlled study. Neurology. 1967;17(2):162-165.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ0775300 CHEMICAL NAME : 4-Imidazolidinone, 5-(2-methylpropyl)-3-(2-propenyl)-2-thioxo- CAS REGISTRY NUMBER : 830-89-7 BEILSTEIN REFERENCE NO. : 0163719 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C10-H16-N2-O-S MOLECULAR WEIGHT : 212.34 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 785 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,107,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 294 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,107,1961 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg/10D-I TOXIC EFFECTS : Endocrine - evidence of thyroid hypofunction Endocrine - changes in thyroid weight Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,107,1961 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10200 mg/kg/17D-I TOXIC EFFECTS : Behavioral - tolerance REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,107,1961

安全

• 海关编码: 2933990090

合成路线

57-06-7 ~% 830-89-7

文献：Oba et al. Nippon Shashin Gakkaishi, 1950 , vol. 13, p. 103,107 Chem.Abstr., 1952 , p. 3885

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%