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盐酸艾司洛尔

盐酸艾司洛尔用途

Esmolol盐酸盐是一种β肾上腺素受体抑制剂。

盐酸艾司洛尔名称

[ CAS 号 ]:
81161-17-3

[ 中文名 ]:
盐酸艾司洛尔

[ 英文名 ]:
Esmolol hydrochloride

[中文别名 ]:

半水盐酸阿扑吗啡

[英文别名 ]:

esmolol hcl
Esmolol Hydrochloride
EsmololHclC16H25No4Hcl
MFCD00941432
UNII:V05260LC8D
Brevibloc
EsMolol Hcl API

盐酸艾司洛尔生物活性

[ 描述 ]:

Esmolol盐酸盐是一种β肾上腺素受体抑制剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

信号通路 >> 自噬 >> 自噬

研究领域 >> 心血管疾病

[相关活性小分子]

盐酸艾司洛尔物理化学性质

[ 密度 ]:
1.026

[ 沸点 ]:
430.2ºC at 760 mmHg

[ 熔点 ]:
48-50ºC

[ 分子式 ]:
C₁₆H₂₆ClNO₄

[ 分子量 ]:
331.835

[ 闪点 ]:
214ºC

[ 精确质量 ]:
331.155029

[ PSA ]:
67.79000

[ LogP ]:
2.72280

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Slightly soluble

盐酸艾司洛尔毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA8346000

CHEMICAL NAME :: Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester, hydrochloride

CAS REGISTRY NUMBER :: 81161-17-3

LAST UPDATED :: 199606

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H25-N-O4.Cl-H

MOLECULAR WEIGHT :: 331.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 775 ug/kg/14M-C

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 22,484,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 71 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 93 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 560 mg/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985

盐酸艾司洛尔安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R52/53

[ 安全声明 (欧洲) ]:
61

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
-

[ RTECS号 ]:
DA8346000

[ 海关编码 ]:
2922199090

盐酸艾司洛尔合成路线

详细合成路线

盐酸艾司洛尔上下游产品

盐酸艾司洛尔上游产品

盐酸艾司洛尔下游产品

盐酸艾司洛尔海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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