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吡啉

吡啉用途

Purpurin 是来自 Rubia tinctorum L. 的天然蒽醌化合物。Purpurin 具有抗抑郁样作用。

吡啉名称

[ CAS 号 ]:
81-54-9

[ 中文名 ]:
吡啉

[ 英文名 ]:
purpurin

[中文别名 ]:

[英文别名 ]:

EINECS 201-359-8
Verantin
Purpurin
1,2,4-Trihydroxy-9,10-anthracenedione
C.I. Natural Red 16
natural red 16
1,2,4-Trihydroxy-9,10-anthraquinone
9,10-Anthracenedione, 1,2,4-trihydroxy-
Purpurine
C.I. Natural Red 8

吡啉生物活性

[ 描述 ]:

Purpurin 是来自 Rubia tinctorum L. 的天然蒽醌化合物。Purpurin 具有抗抑郁样作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体内研究]

紫癜素(口服；2,6,18mg/kg,3周)对成年雄性C57BL/6J小鼠(6-7周龄)的行为和应激轴反应性产生剂量依赖性的抗抑郁样作用[1]。

[参考文献]

[1]. Ma L, et al. Purpurin exerted antidepressant-like effects on behavior and stress axis reactivity: evidence of serotonergic engagement. Psychopharmacology (Berl). 2020 Mar;237(3):887-899.

吡啉物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
525.1±45.0 °C at 760 mmHg

[ 熔点 ]:
253-256ºC(lit.)

[ 分子式 ]:
C₁₄H₈O₅

[ 分子量 ]:
256.210

[ 闪点 ]:
285.4±25.2 °C

[ 精确质量 ]:
256.037170

[ PSA ]:
94.83000

[ LogP ]:
4.60

[ 外观性状 ]:
Powder

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.773

[ 储存条件 ]:
2-8C

[ 水溶解性 ]:
水溶性：微溶；可溶于：甲苯,苯

吡啉MSDS

吡啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB8200000

CHEMICAL NAME :: Anthraquinone, 1,2,4-trihydroxy-

CAS REGISTRY NUMBER :: 81-54-9

BEILSTEIN REFERENCE NO. :: 1887127

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H8-O5

MOLECULAR WEIGHT :: 256.22

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ EQ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 20 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,1,1990

吡啉安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26;S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CB8200000

[ 海关编码 ]:
2914690090

吡啉合成路线

吡啉上下游产品

吡啉上游产品

吡啉下游产品

吡啉海关

[ 海关编码 ]: 2914690090

[ 中文概述 ]:
2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

吡啉文献

Structural and optical properties of Purpurin for dye-sensitized solar cells.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 149 , 997-1008, (2015)

In this work, we reported a combined experimental and theoretical study on molecular structure, vibrational spectra and Homo-Lumo analysis of Purpurin and TiO2/Purpurin. The geometries, electronic str...

Protection against the bacterial mutagenicity of heterocyclic amines by purpurin, a natural anthraquinone pigment.

Mutat. Res. 444(2) , 451-61, (1999)

Purpurin (1,2,4-trihydroxy-9,10-anthraquinone) is a naturally occurring anthraquinone pigment found in species of madder root. We have found that the presence of purpurin in bacterial mutagenicity ass...

Toxicity and tumorigenicity of purpurin, a natural hydroxanthraquinone in rats: induction of bladder neoplasms.

Cancer Lett. 102(1-2) , 193-8, (1996)

Chronic toxicity and tumorigenicity of purpurin, a natural hydroxyanthraquinone, was examined in two groups of male F344 rats. One group was given a basal diet mixed with purpurin at a concentration o...

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吡啉