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呋喃硫胺

呋喃硫胺用途

Fursultiamine 是一种维生素 B1 衍生物。

呋喃硫胺名称

[ CAS 号 ]:
804-30-8

[ 中文名 ]:
呋喃硫胺

[ 英文名 ]:
Fursultiamine

[中文别名 ]:

长效维生素B1

[英文别名 ]:

Linamin
Alinamin F
Diteftin
Thiamine tetrahydrofurfuryl disulfide
MFCD00867383
Retar B1
FURSULTIAMINE
Fursultiamin
Judolor
thiamine tetrahdydrofufuryl disulfide

呋喃硫胺生物活性

[ 描述 ]:

Fursultiamine 是一种维生素 B1 衍生物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[参考文献]

[1]. Kobayashi T, et al. Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritis. Inflamm Res. 2005 Jun;54(6):249-55.

[相关活性小分子]

呋喃硫胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
652.3±55.0 °C at 760 mmHg

[ 熔点 ]:
130-136ºC (decompos.)

[ 分子式 ]:
C₁₇H₂₆N₄O₃S₂

[ 分子量 ]:
398.543

[ 闪点 ]:
348.3±31.5 °C

[ 精确质量 ]:
398.144623

[ PSA ]:
152.17000

[ LogP ]:
2.35

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.626

[ 储存条件 ]:
2-8℃

呋喃硫胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ0750000

CHEMICAL NAME :: Formamide, N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydro xy-1-methyl-2- ((tetrahydrofurfuryl)dithio)-1-butenyl)-

CAS REGISTRY NUMBER :: 804-30-8

BEILSTEIN REFERENCE NO. :: 0052964

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C17-H26-N4-O3-S2

MOLECULAR WEIGHT :: 398.59

WISWESSER LINE NOTATION :: T6N CNJ B1 DZ E1NVHY1&UY2QSS1- BT5OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3016380

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3016380

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,699,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 30,242,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,699,1982