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罗莫肽

罗莫肽用途

罗慕尔肽(Muroctasin)是一种合成的鼠氨酰二肽衍生物,是一种细胞因子诱导剂。罗慕特可在体内增加外周血中性粒细胞和单核细胞,并在体外增强集落刺激因子(CSF)、IL-1和IL-6的产生[1]。

罗莫肽名称

[ CAS 号 ]:
78113-36-7

[ 中文名 ]:
罗莫肽

[ 英文名 ]:
Romurtide

[中文别名 ]:

[英文别名 ]:

罗莫肽生物活性

[ 描述 ]:

罗慕尔肽(Muroctasin)是一种合成的鼠氨酰二肽衍生物,是一种细胞因子诱导剂。罗慕特可在体内增加外周血中性粒细胞和单核细胞,并在体外增强集落刺激因子(CSF)、IL-1和IL-6的产生[1]。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 白细胞介素相关
研究领域 >> 炎症/免疫

[ 靶点 ]

Cytokines[1]


[体外研究]

罗密特显著增强猴外周血单核细胞产生集落刺激因子(CSF)、白介素-1(IL-1)和白介素-6(IL-6)[1]。

[体内研究]

罗慕特(1 mg/头；皮下注射；单剂量)显著增加健康食蟹猴的外周中性粒细胞和单核细胞的数量[1]。动物模型：健康食蟹猴[1]剂量：1 mg/头给药：皮下注射。；单剂量结果：外周血中性粒细胞和单核细胞数量显著增加。

[参考文献]

[1]. Nakajima R, Yshida Y, Akahane K, Sekiguchi M, Osada Y. Stimulatory effect of romurtide on hematopoiesis in monkeys. Arzneimittelforschung. 1991 Jan;41(1):60-5.

罗莫肽物理化学性质

[ 密度 ]:
1.21g/cm3

[ 沸点 ]:
1198.5ºC at 760 mmHg

[ 熔点 ]:
176-178°

[ 分子式 ]:
C43H78N6O13

[ 分子量 ]:
887.11200

[ 闪点 ]:
678.6ºC

[ 精确质量 ]:
886.56300

[ PSA ]:
305.04000

[ LogP ]:
4.36240

[ 折射率 ]:
1.544

罗莫肽MSDS

详细MSDS(安全技术说明书)

罗莫肽毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OL5545000
CHEMICAL NAME :
L-Lysine, N(sup 2),(N(sup 2)-(N-(N-acetylmuramoyl)-L-alanyl)-D-alpha-glutaminyl )-N(sup 6)- (1-oxooctadecyl)-
CAS REGISTRY NUMBER :
78113-36-7
LAST UPDATED :
199612
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C43-H78-N6-O13
MOLECULAR WEIGHT :
887.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,967,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
761 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Behavioral - irritability
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1022,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,967,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,967,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
436 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Behavioral - irritability
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1022,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - dermatitis, irritative (after systemic exposure)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1022,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2800 ug/kg/28D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1024,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
91 mg/kg/26W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1028,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
28 mg/kg/28D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Biochemical - Metabolism (Intermediary) - lipids including transport Related to Chronic Data - changes in prostate weight
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1024,1988 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
100 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1040,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
140 mg/kg
SEX/DURATION :
female 15-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1040,1988

罗莫肽安全信息

[ WGK德国 ]:
3

[ RTECS号 ]:
OL5545000

推荐生产厂家/供应商：

公司名：南京肽业生物科技有限公司

区域：南京市六合区

价格：
￥需询单/10g ￥需询单/100g ￥需询单/1kg ￥需询单/10kg

联系人：范经理

产品详情：Romurtide

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罗莫肽供应商

相关化合物

【罗莫肽】化源网提供罗莫肽CAS号78113-36-7，罗莫肽MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询罗莫肽上化源网，专业又轻松。>>电脑版：罗莫肽

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