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阿奇霉素 A

阿奇霉素 A用途

Azathramycin 是一种抗生素。

阿奇霉素 A名称

[ CAS 号 ]:
76801-85-9

[ 中文名 ]:
阿奇霉素 A

[ 英文名 ]:
Azathramycin

[中文别名 ]:

[英文别名 ]:

9-deokso-9a-aza-9a-homoeritromicin A
Desmethylazithromycin
9a-N-desmethyl azithromycin
DD-Azaerythromycin A
10-Dihydro-10-deoxo-11-azaerythromycin A
9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A
9a-aza-9-deoxo-9a-homoerythromycin A
9-deoxo-9a-aza-9a-homoerythromycin
Azaerythromycin A
UNII-4LSP9FJT5B

阿奇霉素 A生物活性

[ 描述 ]:

Azathramycin 是一种抗生素。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Noedl H, Krudsood S, Leowattana W, In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome. Antimicrob Agents Chemother. 2007 Feb;51(2):651-6.

[2]. Hiwatashi Y, Maeda M, Fukushima H, Azithromycin suppresses proliferation, interleukin production and mitogen-activated protein kinases in human peripheral-blood mononuclear cells stimulated with bacterial superantigen. J Pharm Pharmacol. 2011 Oct;63(10):1320-6.

[3]. Fernandez-Obregon AC. Azithromycin for the treatment of acne. Int J Dermatol. 2000 Jan;39(1):45-50.

[相关活性小分子]

阿奇霉素 A物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
815.2±65.0 °C at 760 mmHg

[ 熔点 ]:
126-136ºC

[ 分子式 ]:
C₃₇H₇₀N₂O₁₂

[ 分子量 ]:
734.958

[ 闪点 ]:
446.8±34.3 °C

[ 精确质量 ]:
734.492859

[ PSA ]:
188.87000

[ LogP ]:
3.11

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
-20℃

阿奇霉素 A安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

阿奇霉素 A合成路线

详细合成路线

阿奇霉素 A上下游产品

阿奇霉素 A上游产品

阿奇霉素 A下游产品

阿奇霉素 A文献

Peptide-mediated macrolide resistance reveals possible specific interactions in the nascent peptide exit tunnel.

Mol. Microbiol. 54(2) , 376-85, (2004)

Expression of specific short peptides can render cells resistant to macrolide antibiotics. Peptides conferring resistance to structurally different macrolides including oleandomycin, azithromycin, aza...

Quantitative thin-layer chromatographic method of analysis of azithromycin in pure and capsule forms.

J. Chromatogr. Sci. 41(1) , 10-6, (2003)

A validated stability-indicating thin-layer chromatographic (TLC) method of the analysis of azithromycin (AZT) in bulk and capsule forms is developed. Both AZT potential impurity and degradation produ...

Erythromycin series. XII. Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A: synthesis and structure-activity relationship of its acyl derivatives.

J. Antibiot. 40(7) , 1006-15, (1987)

Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A (5), the new 15-membered semi-synthetic macrolide antibiotic with nitrogen as additional atom in the aglycone ring of eryt...

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