异丙肾上腺素甲磺酸盐

异丙肾上腺素甲磺酸盐用途

甲磺酸异tharine(isotarine)是一种口服活性的β-肾上腺素能受体选择性激动剂。甲磺酸异tharine是一种邻苯二酚样药物,邻苯二酚O-甲基转移酶(COMT)介导其甲基化。甲磺酸异tharine可以促进cAMP的产生,刺激平滑肌细胞的松弛,可以用作肺气肿、支气管炎和支气管扩张剂[1][2]。

异丙肾上腺素甲磺酸盐名称

[ CAS 号 ]:
7279-75-6

[ 中文名 ]:
异丙肾上腺素甲磺酸盐

[ 英文名 ]:
4-[1-HYDROXY-2-([1-METHYLETHYL]AMINO)BUTYL]-1,2-BENZENEDIOL METHANESULFONATE

[中文别名 ]:

[英文别名 ]:

Isoetharine mesylate salt
EINECS 230-695-8
Isotharine mesylate
ISOETHARINE MESYLATE
Isoetharine mesylate (USP)
Isoetarine mesilate

异丙肾上腺素甲磺酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 炎症/免疫

[体外研究]

甲磺酸异tharine(50μM,18小时)可诱导HepG2人肝癌细胞[1]产生和释放儿茶酚类药物的[35S]硫酸化代谢产物。

[体内研究]

甲磺酸异tharine在斑马鱼幼体模型中抑制黑色素沉积,AC50值为5.10 mM,在7.50 mM时完全抑制色素生成[2]。

[参考文献]

[1]. Katsuhisa Kurogi，et al. Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs. Biochem Pharmacol. 2012 Nov 1;84(9):1186-95.

[2]. Monika Maciag，et al. Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish. Toxicol Appl Pharmacol. 2022 Jan 1;434:115812.

异丙肾上腺素甲磺酸盐物理化学性质

[ 沸点 ]:
429.3ºC at 760 mmHg

[ 分子式 ]:
C₁₄H₂₅NO₆S

[ 分子量 ]:
335.41600

[ 闪点 ]:
156.7ºC

[ 精确质量 ]:
335.14000

[ PSA ]:
135.47000

[ LogP ]:
2.88350

异丙肾上腺素甲磺酸盐MSDS

详细MSDS(安全技术说明书)

异丙肾上腺素甲磺酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

异丙肾上腺素甲磺酸盐文献

Nitric oxide and beta-adrenergic agonist-induced bronchial arterial vasodilation.

J. Appl. Physiol. 82 , 686-692, (1997)

In anesthetized sheep, we measured bronchial blood flow (Qbr) by an ultrasonic flow probe to investigate the interaction between inhaled nitric oxide (NO; 100 parts/million) given for 5 min and 5 ml o...

Non-cAMP-mediated bronchial arterial vasodilation in response to inhaled beta-agonists.

J. Appl. Physiol. 84 , 215-221, (1998)

We studied the dose-dependent effects of inhaled isoetharine HCl, a beta-adrenergic bronchodilator (2.5, 5.0, 10.0, and 20.0 mg), on bronchial blood flow (Qbr) in anesthetized sheep. Isoetharine resul...

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