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次黄嘌呤

次黄嘌呤用途

Hypoxanthine 是嘌呤衍生物,也是一种潜在的自由基发生器,可以作为缺氧指征的指示剂。

次黄嘌呤名称

[ CAS 号 ]:
68-94-0

[ 中文名 ]:
次黄嘌呤

[ 英文名 ]:
Hypoxanthine

[中文别名 ]:

[英文别名 ]:

3,9-Dihydro-6H-purin-6-on
1,7-Dihydro-6H-purin-6-on
6-Oxopurine
1,7-Dihydro-6H-purin-6-one
7H-Purin-6-ol
PURIN-6-OL
Hypexanthine
SARKIN
SARCINE
Hypoxathine

次黄嘌呤生物活性

[ 描述 ]:

Hypoxanthine 是嘌呤衍生物,也是一种潜在的自由基发生器,可以作为缺氧指征的指示剂。

[ 相关类别 ]:

研究领域 >> 其他

天然产物 >> 糖和糖苷

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

次黄嘌呤是一种潜在的自由基生成剂。次黄嘌呤似乎通过氧自由基产生在缺氧复氧细胞损伤中发挥作用,因此参与许多疾病的发病机理。次黄嘌呤还调节许多其他过程,因为它与苯二氮卓受体反应并抑制大脑中的磷酸二酯酶。次黄嘌呤抑制几种细胞毒性药物的作用,因此可能会影响这些药物的治疗[1]。

[体内研究]

在猪中,发现血浆次黄嘌呤随着低氧血症的持续时间线性增加,并且动脉和静脉血浆之间没有差异。次黄嘌呤和乳酸,碱缺乏和pH之间存在良好的相关性。生存时间与血浆次黄嘌呤的增加之间也存在直接关系。存活时间与次黄嘌呤增加率呈负相关(r = -0.62)。当次黄嘌呤超过125 pM /升时,所有动物死亡。因此,次黄嘌呤的增加反映了急性缺氧的预后与基础缺陷相反[1]。

[参考文献]

[1]. Saugstad OD, et al. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

[相关活性小分子]

次黄嘌呤物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
551.0±30.0 °C at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₅H₄N₄O

[ 分子量 ]:
136.111

[ 闪点 ]:
287.0±24.6 °C

[ 精确质量 ]:
136.038513

[ PSA ]:
74.43000

[ LogP ]:
-0.91

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.816

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
practically insoluble

次黄嘌呤MSDS

详细MSDS(安全技术说明书)

次黄嘌呤毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0791000

CHEMICAL NAME :: 6H-Purin-6-one, 1,7-dihydro-

CAS REGISTRY NUMBER :: 68-94-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C5-H4-N4-O

MOLECULAR WEIGHT :: 136.13

WISWESSER LINE NOTATION :: T56 BN DM FVM INJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 600 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 22,201,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1 gm/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 22,201,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6051 No. of Facilities: 64 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 541 (estimated) No. of Female Employees: 355 (estimated)

次黄嘌呤安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25-S37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UP0791000

[ 海关编码 ]:
2933990090

次黄嘌呤上下游产品

次黄嘌呤上游产品

次黄嘌呤下游产品

次黄嘌呤制备

氰乙酸乙酯与乙醇钠、硫脲经环合反应得到2-巯基-4-氨基-6-羟基嘧啶，再经亚硝化、还原、消除、环合，制得6-羟基嘌呤。

次黄嘌呤海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

次黄嘌呤文献

Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: effect of oxidative stress.

Microvasc. Res. 98 , 16-22, (2015)

Adenosine is an endogenous regulator of vascular tone. This activity of adenosine is terminated by its uptake and metabolism by microvascular endothelial cells (MVEC). The predominant transporter invo...

In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells.

PLoS ONE 10 , e0134768, (2015)

Dapsone (DDS) hydroxylamine metabolites cause oxidative stress- linked adverse effects in patients, such as methemoglobin formation and DNA damage. This study evaluated the ameliorating effect of the ...

Oxidative stress modulates nucleobase transport in microvascular endothelial cells

Microvasc. Res. 95 , 68-75, (2014)

Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, ...

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