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梓苷

梓苷用途

梓甙,一种环烯醚萜苷,可从梓卵酸G。Don(Bignoniaceae)抑制脂多糖激活的RAW 264.7巨噬细胞中TNF-α、IL-1β和IL-6的产生以及NF-κB(p65)的激活[1]。

梓苷名称

[ CAS 号 ]:
6736-85-2

[ 中文名 ]:
梓苷

[ 英文名 ]:
Catalposide

[中文别名 ]:

梓苷.梓实糖苷

[英文别名 ]:

Einecs 229-789-1
hydroxybenzoylcatalpol
CATALPOSIDE

梓苷生物活性

[ 描述 ]:

梓甙,一种环烯醚萜苷,可从梓卵酸G。Don(Bignoniaceae)抑制脂多糖激活的RAW 264.7巨噬细胞中TNF-α、IL-1β和IL-6的产生以及NF-κB(p65)的激活[1]。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[体外研究]

梓甙(1-1000 ng/mL)可抑制RAW 264.7巨噬细胞中TNF-a、IL-1β和IL-6的产生[1]。

[参考文献]

[1]. S J An, et al. Inhibition of TNF-alpha, IL-1beta, and IL-6 productions and NF-kappa B activation in lipopolysaccharide-activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae). Int Immunopharmacol. 2002 Jul;2(8):1173-81.

梓苷物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
766.3±60.0 °C at 760 mmHg

[ 熔点 ]:
215-216.5°

[ 分子式 ]:
C₂₂H₂₆O₁₂

[ 分子量 ]:
482.435

[ 闪点 ]:
266.7±26.4 °C

[ 精确质量 ]:
482.142426

[ PSA ]:
187.90000

[ LogP ]:
-2.18

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.696

[ 储存条件 ]:
2-8℃，干燥，密闭

梓苷MSDS

详细MSDS(安全技术说明书)

梓苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ5776783

CHEMICAL NAME :: beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-((4-hydroxybenzoyl)oxy)- 1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran- 2-yl, (1aS-(1a-alpha,1b-beta,2-beta,5a- beta,6-beta,6a-alpha))-

CAS REGISTRY NUMBER :: 6736-85-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H26-O12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,93,1968

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,93,1968

梓苷安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
29389090

梓苷文献

Electrochemical and spectrometric study of antioxidant activity of pomiferin, isopomiferin, osajin and catalposide.

J. Pharm. Biomed. Anal. 48(1) , 127-33, (2008)

The antioxidant properties of pomiferin, isopomiferin, osajin and catalposide are evaluated. The electrochemical behaviour of these compounds at a carbon paste electrode was studied using square wave ...

Hostplant suitability and defensive chemistry of the Catalpa sphinx, Ceratomia catalpae.

J. Chem. Ecol. 29(10) , 2359-67, (2003)

The growth and survival of the Catalpa sphinx, Ceratomia catalpae (Sphingidae), were measured on five different species of Catalpa: C. bignonioides, C. bungeii, C. fargeseii, C. ovata, and C. speciosa...

Inhibition of TNF-alpha, IL-1beta, and IL-6 productions and NF-kappa B activation in lipopolysaccharide-activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae).

Int. Immunopharmacol. 2(8) , 1173-81, (2002)

Catalposide, the major iridoid glycoside isolated from the stem bark of Catalpa ovata G. Don (Bignoniaceae), was found to inhibit the productions of tumor necrosis factor-alpha (TNF-alpha), interleuki...

更多文献

梓苷