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盐酸利多卡因d3

盐酸利多卡因d3用途

盐酸利达脒(WHR-1142A)是一种α2-肾上腺素能受体激动剂和止泻剂[1]。

盐酸利多卡因d3名称

[ CAS 号 ]:
65009-35-0

[ 中文名 ]:
盐酸利多卡因d3

[ 英文名 ]:
Lidamidine hydrochloride

[英文别名 ]:

Einecs 265-307-6
LIDAMIDINE(LIDAMIDIUM) HYDROCHLORIDE
Unii-3Q1Q4qjv3v
Lidamidine hydrochloride
LIDAMIDINE HCL

盐酸利多卡因d3生物活性

[ 描述 ]:

盐酸利达脒(WHR-1142A)是一种α2-肾上腺素能受体激动剂和止泻剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

[参考文献]

[1]. DeLong AF, et al. Pharmacokinetics and disposition of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent, in rat and monkey. Arzneimittelforschung. 1978;28(8a):1477-80.

盐酸利多卡因d3物理化学性质

[ 沸点 ]:
342.4ºC at 760 mmHg

[ 分子式 ]:
C₁₁H₁₇ClN₄O

[ 分子量 ]:
256.73

[ 闪点 ]:
160.9ºC

[ 精确质量 ]:
256.109100

[ PSA ]:
77.01000

[ LogP ]:
3.33560

盐酸利多卡因d3毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU4995000

CHEMICAL NAME :: Urea, 1-(2,6-xylyl)-3-methylamidino-, hydrochloride

CAS REGISTRY NUMBER :: 65009-35-0

LAST UPDATED :: 199306

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H16-N4-O.Cl-H

MOLECULAR WEIGHT :: 256.77

WISWESSER LINE NOTATION :: MUYM1&MVMR B1 F1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 187 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 303 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg/30D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Endocrine - hyperglycemia Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 1140 mg/kg/38D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978