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莱姆勃霉素

莱姆勃霉素用途

Chartreusin 是一种抗生素 (antibiotic),对某些革兰氏阳性菌和分枝杆菌有活性。Chartreusin 对 Micrococcus fiyogenes v. aureus 噬菌体也有活性。

莱姆勃霉素名称

[ CAS 号 ]:
6377-18-0

[ 中文名 ]:
莱姆勃霉素

[ 英文名 ]:
Chartreusin

[中文别名 ]:

教酒菌素

[英文别名 ]:

CHARTREUSIN
antibioticx-465a
u-7257
chartreusin from streptomyces*chartreusis

莱姆勃霉素生物活性

[ 描述 ]:

Chartreusin 是一种抗生素 (antibiotic),对某些革兰氏阳性菌和分枝杆菌有活性。Chartreusin 对 Micrococcus fiyogenes v. aureus 噬菌体也有活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Leach B E, et al. Chartreusin, a new antibiotic produced by Streptomyces chartreusis, a new species. Journal of the American Chemical Society, 1953, 75(16): 4011-4012.

莱姆勃霉素物理化学性质

[ 密度 ]:
1.63g/cm3

[ 沸点 ]:
945.5ºC at 760 mmHg

[ 分子式 ]:
C₃₂H₃₂O₁₄

[ 分子量 ]:
640.58800

[ 闪点 ]:
307.8ºC

[ 精确质量 ]:
640.17900

[ PSA ]:
207.72000

[ LogP ]:
1.36980

[ 折射率 ]:
1.718

[ 储存条件 ]:
库房低温通风干燥

莱姆勃霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FL7350000

CHEMICAL NAME :: Chartreusin

CAS REGISTRY NUMBER :: 6377-18-0

BEILSTEIN REFERENCE NO. :: 0075649

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C32-H32-O14

MOLECULAR WEIGHT :: 640.64

WISWESSER LINE NOTATION :: T B66 K666 2AB T HVO SVOJ F1 QQ LO- BT6OTJ DQ EQ F1 CO- BT6OTJ CQ DO1 EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 5 mg/L

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 34,173,1981