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甲氧基乙酸甲酯

甲氧基乙酸甲酯用途

【用途一】
用作医药、农药、染料中间体，医药上用于合成维生素B6
【用途二】
医药合成的中间体，主要用来合成周效磺胺、维生素B6等。

甲氧基乙酸甲酯名称

[ CAS 号 ]:
6290-49-9

[ 中文名 ]:
甲氧基乙酸甲酯

[ 英文名 ]:
Methyl methoxyacetate

[中文别名 ]:

甲氧基乙酸甲酸

[英文别名 ]:

Acetic acid, 2-methoxy-, methyl ester
Methyl methoxyacetate
EINECS 228-539-9
MFCD00008451

甲氧基乙酸甲酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
131.0±0.0 °C at 760 mmHg

[ 分子式 ]:
C₄H₈O₃

[ 分子量 ]:
104.104

[ 闪点 ]:
34.1±11.4 °C

[ 精确质量 ]:
104.047340

[ PSA ]:
35.53000

[ LogP ]:
0.01

[ 外观性状 ]:
透明无色液体

[ 蒸汽压 ]:
9.5±0.2 mmHg at 25°C

[ 折射率 ]:
1.379

[ 储存条件 ]:
Flammables area

[ 水溶解性 ]:
soluble

甲氧基乙酸甲酯MSDS

甲氧基乙酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AI8910000

CHEMICAL NAME :: Acetic acid, methoxy-, methyl ester

CAS REGISTRY NUMBER :: 6290-49-9

BEILSTEIN REFERENCE NO. :: 1742944

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H8-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,Feb,1942

甲氧基乙酸甲酯安全信息

[ 符号 ]:

GHS02

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R10

[ 安全声明 (欧洲) ]:
S16-S29-S33

[ 危险品运输编码 ]:
UN 3272 3/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
AI8910000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
29189090

甲氧基乙酸甲酯合成路线

甲氧基乙酸甲酯上下游产品

甲氧基乙酸甲酯上游产品

甲氧基乙酸甲酯下游产品

甲氧基乙酸甲酯制备

1. 以氯乙酸甲酯和甲醇钠为原料在甲醇中进行甲氧基化反应。反应完成后经过滤分离盐分，再经蒸馏脱溶剂，然后在减压下精馏的成品：

2.制法：

于装有搅拌器、滴液漏斗、回流冷凝器的反应瓶中，加入无水甲醇1.5L，甲醇钠，不断搅拌下慢慢加入氯乙酸甲酯（2）3Kg，而后于65℃搅拌反应3h。注意控制反应液的PH值保持在8～9之间，必要时可加入甲醇钠进行调节。冷却，滤去氯化钠固体，用甲醇洗涤。合并滤液和洗涤液，蒸出甲醇后减压蒸馏，得甲氧基乙酸甲酯（1），收率95%。

甲氧基乙酸甲酯海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

甲氧基乙酸甲酯文献

Predicting and avoiding subcellular compartmentalization artifacts arising from acetoxymethyl ester calcium imaging probes. The case of fluo-3 AM and a general account of the phenomenon including a problem avoidance chart.

Biotech. Histochem. 87(7) , 468-83, (2012)

Stimulated by difficulties experienced when using fluo-3 AM, we developed a general mechanistic model to aid understanding and practical application of calcium probes applied as acetoxymethyl (AM) est...

[Information from the Soviet Toxicology Center].

Farmakol. Toksikol. 43(6) , 750-1, (1980)

Regional difference in stainability with calcium-sensitive acetoxymethyl-ester probes in mouse brain slices.

Int. J. Neurosci. 119(2) , 214-26, (2009)

Loading neurons with membrane permeable Ca2+ indicators is a core experimental procedure in functional multineuron Ca2+ imaging (fMCI), an optical technique for monitoring multiple neuronal activities...

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