1-硝基丙三醇
1-硝基丙三醇名称
[ CAS 号 ]:
624-43-1
[ 中文名 ]:
1-硝基丙三醇
[ 英文名 ]:
1-MONONITROGLYCERIN
[英文别名 ]:
- 1,2,3-Propanetriol,1-nitrate
- Glycerol-1-nitrate
- Glycerol-1-nitrat
- glyceryl 1-mononitrate
- Glycerol 1-mononitrate
- glycerol nitrate
- propylene glycol 1-nitrate
- Glycerol-1-mononitrat
- 1-Mononitroglycerin
- 1-Mononitroglycerol
1-硝基丙三醇物理化学性质
[ 分子式 ]:
C3H7NO5
[ 分子量 ]:
137.09100
[ 精确质量 ]:
137.03200
[ PSA ]:
95.51000
1-硝基丙三醇毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MB0200000
- CHEMICAL NAME :
- Glycerol, 1-nitrate
- CAS REGISTRY NUMBER :
- 624-43-1
- BEILSTEIN REFERENCE NO. :
- 1761580
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C3-H7-N-O5
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 339 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 580 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1433 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3160 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,814,1986
1-硝基丙三醇安全信息
[ 符号 ]:
GHS02, GHS07
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H302 + H312 + H332-H319
[ 警示性声明 ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235
[ 危险品运输编码 ]:
UN 1648 3 / PGII
1-硝基丙三醇合成路线
1-硝基丙三醇上下游产品
1-硝基丙三醇上游产品
1-硝基丙三醇下游产品
1-硝基丙三醇文献
Clin. Exp. Pharmacol. Physiol. 16(11) , 829-35, (1989)
1. The present study has examined the possibility that one or more metabolites of glyceryl trinitrate (GTN) (i.e. glyceryl-1,2- and -1,3-dinitrate and glyceryl-1- and -2-mononitrate) may be responsibl...
Guanylate cyclase activation by organic nitrates is not mediated via nitrite.J. Mol. Cell. Cardiol. 20(5) , 389-96, (1988)
Nitrovasodilators relax vascular smooth muscle by stimulating guanylate cyclase. Ignarro et al. (1981) proposed a mechanistic scheme according to which organic nitrates release nitrite in the presence...
[Comparative pharmacology of glycerol-1-nitrate and glyceryl trinitrate in various species].Arzneimittelforschung 36(5) , 814-21, (1986)
The present studies yield that all 4 metabolites of glyceryl trinitrate (Nitro Mack, GTN) cause the same typical pharmacological effects as the parent substance. Continuous infusion of 4 mg/kg/min of ...
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