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DL-天门冬氨酸

DL-天门冬氨酸用途

用于氨基酸输液、合成药，可用于肝病及心脏病的治疗，也用于化妆品
用作生化试剂、有机合成中间体及金属络合剂
用于生化研究
营养增补剂
生化及医学临床研究，微生物培养基

DL-天门冬氨酸名称

[ CAS 号 ]:
617-45-8

[ 中文名 ]:
DL-天冬氨酸

[ 英文名 ]:
DL-Aspartic Acid

[中文别名 ]:

[英文别名 ]:

2-Aminosuccinic acid
H-DL-Asp-OH
DL-Asparagic acid
DL-Aminosuccinic acid
DL-2-Aminobutanedioic acid
MFCD00063081
Asparaginic acid
Aminosuccinic acid
Aspartic acid
DL-Aspartic acid

DL-天门冬氨酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
264.1±30.0 °C at 760 mmHg

[ 熔点 ]:
300ºC

[ 分子式 ]:
C₄H₇NO₄

[ 分子量 ]:
133.103

[ 闪点 ]:
113.5±24.6 °C

[ 精确质量 ]:
133.037506

[ PSA ]:
100.62000

[ LogP ]:
-0.67

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.531

[ 储存条件 ]:
通风低温干燥

[ 水溶解性 ]:
SOLUBLE | SOLUBLE

DL-天门冬氨酸MSDS

DL-天门冬氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI9097800

CHEMICAL NAME :: DL-Aspartic acid

CAS REGISTRY NUMBER :: 617-45-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C4-H7-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(5),17,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10583 mg/kg/1W-C

TOXIC EFFECTS :: Behavioral - fluid intake Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,738,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4646 No. of Facilities: 473 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 4699 (estimated) No. of Female Employees: 2533 (estimated)

DL-天门冬氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CI9097800

[ 海关编码 ]:
29224995

DL-天门冬氨酸合成路线

DL-天门冬氨酸上下游产品

DL-天门冬氨酸上游产品

DL-天门冬氨酸下游产品

DL-天门冬氨酸制备

以顺丁烯二酸酐为原料，加入苄氨回流数小时，丙酮沉淀、重结晶，然后催化氢化，精制得产物。
由顺丁烯二酸酮与苄胺反应，后经丙酮沉淀、乙醇中结晶，用乙醚萃取再经酸化、氢化后精制而成。

DL-天门冬氨酸海关

[ 海关编码 ]: 29224995

DL-天门冬氨酸文献

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

J. Mol. Biol. 426(24) , 4049-60, (2014)

Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress respons...

Mechanism of chemical activation of sodium chloride in the presence of amino acids.

Food Chem. 166 , 301-8, (2014)

Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indi...

EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake.

J. Neurosci. 34(40) , 13472-85, (2014)

The EAAT2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. Although EAAT2 is predominantly expressed in astrocytes, ∼10% of EAAT2 molecules are found in axon terminals. Despit...

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