氯乙酸乙酯

氯乙酸乙酯用途

【用途一】
用作制药、香料的原料，也用作溶剂
【用途二】
用作溶剂，也用于有机合成
【用途三】
氯乙酸乙酯可用作制备杀虫剂唑蚜威和除草剂草除灵乙酯的原料，也可用于合成抗肿瘤药5-氟尿嘧啶和香料等。
【用途四】
用作溶剂和有机合成原料。用来制取抗肿瘤药物5-氟脲嘧啶、香料及毒气。
【用途五】
用作溶剂和有机合成原料。用来制取抗肿瘤药物5-氟脲嘧啶、香料及军用毒气。

氯乙酸乙酯名称

[ CAS 号 ]:
105-39-5

[ 中文名 ]:
氯乙酸乙酯

[ 英文名 ]:
ethyl chloroacetate

[中文别名 ]:

乙基氯醋酸

[英文别名 ]:

ethyl 2-chloroacetate
Chloroacetic Acid Ethyl Ester
EINECS 203-294-0
MFCD00000932

氯乙酸乙酯物理化学性质

[ 密度 ]:
1.15

[ 沸点 ]:
143 °C(lit.)

[ 熔点 ]:
-26 °C

[ 分子式 ]:
C₄H₇ClO₂

[ 分子量 ]:
122.55000

[ 闪点 ]:
150 °F

[ 精确质量 ]:
122.01300

[ PSA ]:
26.30000

[ LogP ]:
0.78830

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
4.39mmHg at 25°C

[ 折射率 ]:
n20/D 1.421(lit.)

[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放

[ 稳定性 ]:
Stable. Incompatible with acids, bases, oxidizing agents, reducing agents. Flammable.

[ 水溶解性 ]:
20 g/L (20 ºC)

氯乙酸乙酯MSDS

氯乙酸乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AF9110000

CHEMICAL NAME :: Acetic acid, chloro-, ethyl ester

CAS REGISTRY NUMBER :: 105-39-5

BEILSTEIN REFERENCE NO. :: 0506455

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C4-H7-Cl-O2

MOLECULAR WEIGHT :: 122.56

WISWESSER LINE NOTATION :: G1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,587,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 235 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(5),59,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(5),59,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 3,99,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,417,1977 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2940 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,391,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83397 No. of Facilities: 41 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 290 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83397 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 919 (estimated) No. of Female Employees: 306 (estimated)

氯乙酸乙酯安全信息

[ 符号 ]:

GHS02, GHS05, GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H301-H311-H318-H331-H400

[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R10;R23/24/25;R50

[ 安全声明 (欧洲) ]:
S45-S61-S7/9-S16

[ 危险品运输编码 ]:
UN 1181 6.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
AF9110000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2905199090

氯乙酸乙酯合成路线

氯乙酸乙酯上下游产品

氯乙酸乙酯上游产品

氯乙酸乙酯下游产品

氯乙酸乙酯制备

由氯乙酸与乙醇酯化而得。氯乙酸和乙醇以硫酸为催化剂直接酯化。粗酯经碱洗中和、水洗、精馏得成品。

氯乙酸乙酯海关

[ 海关编码 ]: 2905199090

[ 中文概述 ]:
2905199090. 其他饱和一元醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905199090. saturated monohydric alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

氯乙酸乙酯文献

Paracatalytic inactivation of L-2-haloacid dehalogenase from Pseudomonas sp. YL by hydroxylamine. Evidence for the formation of an ester intermediate.

J. Biol. Chem. 272(6) , 3363-8, (1997)

Asp10 of L-2-haloacid dehalogenase from Pseudomonas sp. YL was proposed to act as a nucleophile to attack the alpha-carbon of L-2-haloalkanoic acids to form an ester intermediate, which is hydrolyzed ...

The ethylester of monochloroacetic acid.

Contact Dermatitis 16(2) , 114-5, (1987)

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