过氧化苯甲酸叔丁酯

过氧化苯甲酸叔丁酯用途

【用途一】
用作高压聚乙烯的引发剂、硅橡胶硫化剂、不饱和聚酯固化剂
【用途二】
该品可作不饱和聚酯树脂加热成型的固化引发剂，以及高压聚乙烯、聚苯乙烯、邻苯二甲酸二烯丙酯（DAP）等各种树脂的聚合催化剂。大鼠经口LD50为4160mg/kg，小鼠经口LD50为2500mg/kg。
【用途三】
该品可作不饱和聚酯树脂加热成型的固化引发剂，以及高压聚乙烯、聚苯乙烯、邻苯二甲酸二烯丙酯（DAP）等各种树脂的聚合催化剂。

过氧化苯甲酸叔丁酯名称

[ CAS 号 ]:
614-45-9

[ 中文名 ]:
过氧化苯甲酸叔丁酯

[ 英文名 ]:
tert-Butyl peroxybenzoate

[中文别名 ]:

[英文别名 ]:

esperox10
Luperox P
TBPB
2-Methyl-2-propanyl benzenecarboperoxoate
chaloxydtbpb
UNII:54E39145KT
perbutylz
EINECS 210-382-2
Benzoyl tert-butyl peroxide
t-Bu peroxybenzoate

过氧化苯甲酸叔丁酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
282.4±9.0 °C at 760 mmHg

[ 熔点 ]:
8 °C

[ 分子式 ]:
C₁₁H₁₄O₃

[ 分子量 ]:
194.227

[ 闪点 ]:
109.7±12.8 °C

[ 精确质量 ]:
194.094299

[ PSA ]:
35.53000

[ LogP ]:
3.33

[ 外观性状 ]:
淡黄色液体

[ 蒸汽密度 ]:
6.7 (vs air)

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.497

[ 储存条件 ]:
库房通风低温,轻装轻卸,与有机物、还原剂、硫、磷易燃物分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with a wide range of organic materials - oxidizer. May react violently with organic compounds.

[ 水溶解性 ]:
Immiscible

过氧化苯甲酸叔丁酯MSDS

详细MSDS(安全技术说明书)

过氧化苯甲酸叔丁酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SD9450000

CHEMICAL NAME :: Peroxybenzoic acid, tert-butyl ester

CAS REGISTRY NUMBER :: 614-45-9

BEILSTEIN REFERENCE NO. :: 1342734

LAST UPDATED :: 199712

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C11-H14-O3

MOLECULAR WEIGHT :: 194.25

WISWESSER LINE NOTATION :: 1X1&1&OOVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1012 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >57 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 914 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - necrotic changes

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >57 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32500 mg/kg/13W-I

TOXIC EFFECTS :: Gastrointestinal - other changes Endocrine - changes in spleen weight Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 mg/m3/4H

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32500 mg/kg/13W-I

TOXIC EFFECTS :: Gastrointestinal - other changes Endocrine - changes in spleen weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 311 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 67 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 7),1,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82135 No. of Facilities: 140 (estimated) No. of Industries: 6 No. of Occupations: 16 No. of Employees: 8562 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82135 No. of Facilities: 1326 (estimated) No. of Industries: 25 No. of Occupations: 26 No. of Employees: 27644 (estimated) No. of Female Employees: 10655 (estimated)

过氧化苯甲酸叔丁酯安全信息

[ 符号 ]:

GHS02, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H242-H315-H317-H332-H400

[ 警示性声明 ]:
P210-P220-P234-P261-P273-P280-P370 + P378-P410-P411 + P235-P420

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
E:Explosive

[ 风险声明 (欧洲) ]:
R2;R38;R7

[ 安全声明 (欧洲) ]:
S7-S14-S36/37/39-S47-S37-S17

[ 危险品运输编码 ]:
UN 3103 5.2

[ WGK德国 ]:
2

[ RTECS号 ]:
SD9450000

[ 包装等级 ]:
II

[ 危险类别 ]:
5.2

[ 海关编码 ]:
29163900

过氧化苯甲酸叔丁酯合成路线

详细合成路线

过氧化苯甲酸叔丁酯上下游产品

过氧化苯甲酸叔丁酯上游产品

过氧化苯甲酸叔丁酯下游产品

过氧化苯甲酸叔丁酯制备

(1)叔丁醇硫酸酯的合成将叔丁醇加入反应釜，然后在搅拌下缓缓加入70%的硫酸，保持温度30℃以下，搅拌下进行反应。反应生成的叔丁醇硫酸酯备用。

(2)过氧化叔丁基的合成将双氧水加入反应釜，搅拌下冷却至10～20℃，然后以较快的速度将已制备的叔丁醇硫酸酯加入，搅拌2h，静置分层。分出水层后，用碳酸镁溶液中和至pH为6～7，经低温洗涤而得过氧化叔丁基。

(3)引发剂C的合成将30%的氢氧化钾(或氢氧化钠)溶液和苯甲酰氯在激烈地搅拌下加入到已制备的过氧化叔丁基中，进行反应。反应结束后，产物经洗涤、干燥即得成品。

生产过程所产氯化氢用氢氧化钾吸收、浓缩可得副产品氯化钾。

4. 叔丁基过氧化苯甲酸酯的合成　将30%的氢氧化钠投入如已置有叔丁基过氧化氢的反应釜中，加适量清水，并用－5℃以下的冷冻盐水冷却，使之变成25℃以下的糊状物质，开始滴加定量的苯甲酰氯，维持温度在30℃以下，注意控制滴加速度。加完后保温数小时，并维持釜内溶液pH值在10～14之间。反应结束后，停止搅拌，静置分层。放出下层废液；上层油层用10%的碳酸钠洗涤分离，再3%的氢氧化钠洗涤分离，然后继续用清水洗涤三次、硫酸镁溶液洗涤一次，最后将油层放入贮罐内，加无水硫酸镁干燥过夜，所得澄清无色或淡黄色油状液体即为产品。该步反应式

过氧化苯甲酸叔丁酯海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

过氧化苯甲酸叔丁酯文献

Evidence for the metabolism of tumor promoter organic hydroperoxides into free radicals by human carcinoma skin keratinocytes: an ESR-spin trapping study.

Carcinogenesis 10(8) , 1499-503, (1989)

Humans are exposed to various peroxy and hydroperoxy compounds which are in use in the cosmetic, pharmaceutical and polymer industries and which are also generated as a result of the peroxidative meta...

Exposure of mouse skin to organic peroxides: subchronic effects related to carcinogenic potential.

Carcinogenesis 25(3) , 431-7, (2004)

Screening of newly synthesized organic peroxides for tumor initiating/promoting activity would be greatly facilitated if predictive methodologies could be developed using topical exposures shorter tha...

tert-Butyl peroxybenzoate (TBPB)-mediated 2-isocyanobiaryl insertion with 1,4-dioxane: efficient synthesis of 6-alkyl phenanthridines via C(sp3)-H/C(sp2)-H bond functionalization.

Chem. Commun. (Camb.) 50(49) , 6439-42, (2014)

An efficient method for the construction of 6-alkyl phenanthridines by tert-butyl peroxybenzoate (TBPB)-mediated 2-isocyanobiaryl insertion with 1,4-dioxane was established. Two new C-C bonds were for...

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