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Roquefortine C

Roquefortine C用途

Roquefortine C 是一种从罗氏青霉分离的真菌环肽,可激活 P-gp 并抑制 P450-3A和其他血红蛋白。Roquefortine C 对革兰氏阳性细菌具有抑菌活性。

Roquefortine C名称

[ CAS 号 ]:
58735-64-1

[ 中文名 ]:
异烟棒曲霉素C

[ 英文名 ]:
isoroquefortine C

[英文别名 ]:

isoroquefortine C
roquefortine from penicillium*roqueforti
isoroquefortine
Roquefortin
PYRAZINO1215PYRROLO23BINDOLE143H5AH
RORIFONE
ROQUEFORTINE

Roquefortine C生物活性

[ 描述 ]:

Roquefortine C 是一种从罗氏青霉分离的真菌环肽,可激活 P-gp 并抑制 P450-3A和其他血红蛋白。Roquefortine C 对革兰氏阳性细菌具有抑菌活性。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

信号通路 >> 跨膜转运 >> P-糖蛋白

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. García-Rico RO, et al. Effect of a heterotrimeric G protein alpha subunit on conidia germination, stress response, and roquefortine C production in Penicillium roqueforti. Food Addit Contam. 2005 Apr;22(4):361-8.

Roquefortine C物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
768.3±60.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₂₃N₅O₂

[ 分子量 ]:
389.450

[ 闪点 ]:
418.4±32.9 °C

[ 精确质量 ]:
389.185181

[ PSA ]:
90.12000

[ LogP ]:
1.40

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.687

[ 储存条件 ]:
-20°C，密闭，干燥

Roquefortine CMSDS

详细MSDS(安全技术说明书)

Roquefortine C毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ4730500

CAS REGISTRY NUMBER :: 58735-64-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H23-N5-O2

MOLECULAR WEIGHT :: 389.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,140,1976

Roquefortine C安全信息

[ 风险声明 (欧洲) ]:
23/24/25

[ 安全声明 (欧洲) ]:
22-36/37/39-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ 海关编码 ]:
2933990090

Roquefortine C海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Roquefortine C文献

Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway.

J. Biol. Chem. 288(52) , 37289-95, (2013)

Metabolic profiling and structural elucidation of novel secondary metabolites obtained from derived deletion strains of the filamentous fungus Penicillium chrysogenum were used to reassign various pre...

Determination of selected mycotoxins in mould cheeses with liquid chromatography coupled to tandem with mass spectrometry.

Food Addit. Contam. 22(5) , 449-56, (2005)

A simple and feasible method is described for analysing nine mycotoxins in cheese matrix. The method involves liquid extraction followed by high performance liquid chromatographic separation and mass ...

A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum.

Chem. Biol. 18(11) , 1499-512, (2011)

A single gene cluster of Penicillium chrysogenum contains genes involved in the biosynthesis and secretion of the mycotoxins roquefortine C and meleagrin. Five of these genes have been silenced by RNA...

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