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7β-羟基胆固醇

7β-羟基胆固醇用途

7β-羟基胆固醇是一种氧化甾醇,由胆固醇氧化而得。7β-羟基胆固醇是一种强大的氧化应激诱导剂,可诱导细胞器(线粒体、溶酶体和过氧化物酶体)功能障碍,从而导致细胞死亡[1]。

7β-羟基胆固醇名称

[ CAS 号 ]:
566-27-8

[ 中文名 ]:
胆甾-5-烯-3,7二醇

[ 英文名 ]:
7Beta-Hydroxycholesterol

[中文别名 ]:

[英文别名 ]:

5-Cholestene-3β,7β-diol
7β-hydroxycholesterol
7BETA-HYDROXYCHOLESTEROL
Cholest-5-ene-3,7-diol, (3β,7β,8ξ)-
7β-Hydroxy Cholesterol
(3β,7β,8ξ)-Cholest-5-ene-3,7-diol

7β-羟基胆固醇生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[参考文献]

[1]. Anne Vejux, et al. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 2020 Mar;173:113648.

7β-羟基胆固醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
515.3±38.0 °C at 760 mmHg

[ 熔点 ]:
165-167ºC

[ 分子式 ]:
C₂₇H₄₆O₂

[ 分子量 ]:
402.653

[ 闪点 ]:
214.7±21.4 °C

[ 精确质量 ]:
402.349792

[ PSA ]:
40.46000

[ LogP ]:
7.94

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
-20°C，密闭，干燥

7β-羟基胆固醇MSDS

详细MSDS(安全技术说明书)

7β-羟基胆固醇安全信息

[ 安全声明 (欧洲) ]:
S22-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

7β-羟基胆固醇文献

Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolaemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers.

Br. J. Nutr. 114 , 368-75, (2015)

Toxic oxysterols in a hypercholesterolaemia-relevant proportion cause suicidal death of human erythrocytes or eryptosis. This process proceeds through early production of reactive oxygen species (ROS)...

Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes.

Biochem. Pharmacol. 86(1) , 67-79, (2013)

There is some evidence that oxidized derivatives of cholesterol, 7-ketocholesterol (7KC) and 7β-hydroxycholesterol (7βOHC), are increased in the plasma of patients with neurodegenerative diseases asso...

[Cerebrotendinous xanthomatosis is a rare disorder, which requires a specific treatment].

Ugeskr. Laeg. 175(5) , 285-6, (2013)

Cerebrotendinous xanthomatosis (CTX) is a rare, but treatable lipid storage disorder caused by mutation in the CYP27A1 gene. The disorder results in deposition of cholestanol in various tissues. The c...

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