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DL-甘油醛

DL-甘油醛用途

DL甘油醛是一种单糖。DL甘油醛是最简单的醛糖。DL甘油醛可用于各种生物化学研究[1]。

DL-甘油醛名称

[ CAS 号 ]:
56-82-6

[ 中文名 ]:
DL-甘油醛

[ 英文名 ]:
DL-Glyceric aldehyde

[中文别名 ]:

[英文别名 ]:

a,b-Dihydroxypropionaldehyde
EINECS 200-290-0
DL-Glyceraldehyde
Glyceraldehyde, (±)-
potassium DL-glutamate monohydrate
(±)-glyceraldehyde
2,3-Dihydroxypropanal
Glyceraldehyde
Propanal, 2,3-dihydroxy-
glycerose

DL-甘油醛生物活性

[ 描述 ]:

DL甘油醛是一种单糖。DL甘油醛是最简单的醛糖。DL甘油醛可用于各种生物化学研究[1]。

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Yoshie T, et al. Regulation of the metabolite profile by an APC gene mutation in colorectal cancer. Cancer Sci. 2012;103(6):1010-1021.

DL-甘油醛物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
228.0±0.0 °C at 760 mmHg

[ 熔点 ]:
144-145ºC(lit.)

[ 分子式 ]:
C₃H₆O₃

[ 分子量 ]:
90.08

[ 闪点 ]:
106.0±14.7 °C

[ 精确质量 ]:
90.031693

[ PSA ]:
57.53000

[ LogP ]:
-1.59

[ 外观性状 ]:
白色或灰白色粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.454

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Very soluble (1000 g/L) (25 ºC)

DL-甘油醛MSDS

DL-甘油醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA6475000

CHEMICAL NAME :: Glyceraldehyde, DL-

CAS REGISTRY NUMBER :: 56-82-6

BEILSTEIN REFERENCE NO. :: 0635844

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C3-H6-O3

MOLECULAR WEIGHT :: 90.09

WISWESSER LINE NOTATION :: VHYQ1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 47,2461,1983

DL-甘油醛安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MA6475000

DL-甘油醛合成路线

DL-甘油醛上下游产品

DL-甘油醛上游产品

DL-甘油醛下游产品

DL-甘油醛制备

1.将50g（0.3mol）二乙醇缩DL-甘油醛和500ml0.1mol/L硫酸混合，在20℃放置7d。加入30ml冰乙酸后，用氢氧化钡溶液中和，加5g活性炭，搅拌，过滤。滤液减压蒸发水分至尽，向剩余物中加入等体积无水乙醇，滤出晶体，干燥，得22gDL-甘油醛，收率80%。

2.制法：

二乙醇缩-β-氯乙醛(3)：于装有搅拌器、通气导管的3L反应瓶中，加入无水乙醇253mL，冰盐浴冷至0℃以下，通入干燥的氯化氢气体至饱和。搅拌下滴加冷至0℃的丙烯醛(2)112g(2.0mol),控制反应温度为0℃，约1.5h加完。静置分层，分出下层有机层，分批加入固体碳酸氢钠粉末，中和除酸。过滤，滤液用冰水洗涤，无水碳酸钾干燥10h。过滤后减压蒸馏，收集58～62℃/1.06kPa的馏分，得二乙醇缩-β-氯乙醛(3)112g，收率34%。二乙醇缩丙烯醛(4)：于蒸馏瓶中加入干燥的粉末状的氢氧化钾340g(6mol),上述化合物(3)167g(1.0mol),剧烈摇动后，装上分馏装置。将蒸馏瓶于210～220℃的油浴中加热，直至不再有馏出物馏出为止。分去馏出物中的水，有机层用碳酸钾干燥，过滤后蒸馏，收集122～126℃的馏分，得二乙醇缩丙烯醛(4)98g，收率75%。二乙醇缩甘油醛(5):于装有搅拌器、温度计、滴液漏斗的反应瓶中，加入二乙醇缩丙烯醛(4)65g(0.5mol),水600mL，冷至5℃，搅拌下滴加80g(0.5mol)水配成的溶液，控制滴加速度约25mL/min，反应液温度在5℃左右。搅拌—停止，反应物即变成凝胶状。放置2h后，于蒸汽浴加热1h。抽滤，二氧化锰用150mL水洗涤。合并滤液与洗涤液，冷却下加入1200g无水碳酸钾。分出有机层，水层用乙醚提取4次，合并有机层，无水碳酸钾干燥。回收乙醚后减压蒸馏，收集120～121℃/1.06kPa的馏分，得二乙醇缩甘油醛(5)55g，收率67%。DL-甘油醛(1):将上述二乙醇缩甘油醛(5)50g(0.3mol)和0.05mol/L的硫酸置于反应瓶中，于20℃放置1周。加入30mL冰醋酸。将反应化合物仔细地用氢氧化钡溶液中和，活性炭脱色。过滤，滤液于1.33kPa压力浓缩。剩余物加入等体积的无水乙醇，慢慢析晶。过滤析出的结晶，于盛有钠石灰和氯化钙干燥剂的真空干燥器中真空干燥，得DL-甘油醛(1)22g,收率80%。

DL-甘油醛文献

Vegetables' juice influences polyol pathway by multiple mechanisms in favour of reducing development of oxidative stress and resultant diabetic complications.

Pharmacogn. Mag. 10(Suppl 2) , S383-91, (2014)

Hyperglycemia induced generation of free radicals and consequent development of oxidative stress by polyol pathway is one of the crucial mechanisms stirring up development of diabetic complications. W...

Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.

Naunyn Schmiedebergs Arch. Pharmacol. 387(9) , 849-59, (2014)

Elevated polyol pathway enzyme activities and oxidative stress play an important role in the development and progression of diabetic nephropathy. Here, we investigated the beneficial influence of nige...

Triosephosphate isomerase of Taenia solium (TTPI): phage display and antibodies as tools for finding target regions to inhibit catalytic activity.

Parasitol. Res. 114(1) , 55-64, (2015)

Previous studies demonstrated that antibodies against triosephosphate isomerase of Taenia solium (TTPI) can alter its enzymatic catalysis. In the present study, we used antibodies produced against the...

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