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紫苏酮

紫苏酮用途

紫苏酮是一种天然存在的外源化合物。紫苏酮被肺中的肺P450细胞色素酶激活,导致严重的肺损伤和弥漫性肺水肿[1]。

紫苏酮名称

[ CAS 号 ]:
553-84-4

[ 中文名 ]:
1-呋喃-3-基-4-甲基-1-戊酮

[ 英文名 ]:
1-Pentanone,1-(3-furanyl)-4-methyl-

[英文别名 ]:

Perilla ketone
1-furan-3-yl-4-methyl-pentan-1-one
Purple mint plant extract

紫苏酮生物活性

[ 描述 ]:

紫苏酮是一种天然存在的外源化合物。紫苏酮被肺中的肺P450细胞色素酶激活,导致严重的肺损伤和弥漫性肺水肿[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Alan R Doster, et al. Bovine atypical interstitial pneumonia. Vet Clin North Am Food Anim Pract. 2010 Jul;26(2):395-407.

紫苏酮物理化学性质

[ 密度 ]:
0.976g/cm3

[ 沸点 ]:
224.4ºC at 760mmHg

[ 分子式 ]:
C₁₀H₁₄O₂

[ 分子量 ]:
166.21700

[ 闪点 ]:
96.8ºC

[ 精确质量 ]:
166.09900

[ PSA ]:
30.21000

[ LogP ]:
2.89850

[ 折射率 ]:
1.465

[ 储存条件 ]:
2-8°C，密封，干燥，惰性气体

紫苏酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SA8935000

CHEMICAL NAME :: 1-Pentanone, 1-(3-furanyl)-4-methyl-

CAS REGISTRY NUMBER :: 553-84-4

BEILSTEIN REFERENCE NO. :: 0114624

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H14-O2

MOLECULAR WEIGHT :: 166.24

WISWESSER LINE NOTATION :: T5OJ CV2Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 197,573,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 197,573,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 106 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema

REFERENCE :: JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 60,248,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema

REFERENCE :: JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 60,248,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 13700 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema

REFERENCE :: JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 60,248,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,300,1978

紫苏酮安全信息

[ 海关编码 ]:
2932190090

紫苏酮合成路线

详细合成路线

紫苏酮上下游产品

紫苏酮上游产品

紫苏酮下游产品

紫苏酮海关

[ 海关编码 ]: 2932190090

[ 中文概述 ]:
2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

紫苏酮