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樱黄素

樱黄素用途

Prunetin 是一种 O-甲基化异黄酮,具有抗炎活性。Prunetin 是一种有效的人醛脱氢酶抑制剂。

樱黄素名称

[ CAS 号 ]:
552-59-0

[ 中文名 ]:
樱黄素

[ 英文名 ]:
Prunetin

[中文别名 ]:

[英文别名 ]:

Prunusetin
5,4'-dihydroxy-7-methoxyisoflavone
Prunetin
7-methoxy-4',5-dihydroxyisoflavone
7-O-methyl-genistein
4',5-dihydroxy-7-methoxyisoflavone
4',5-dihydroxy-7-methoxygenistein
EINECS 209-018-5
MFCD00016951

樱黄素生物活性

[ 描述 ]:

Prunetin 是一种 O-甲基化异黄酮,具有抗炎活性。Prunetin 是一种有效的人醛脱氢酶抑制剂。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 醛脱氢酶(ALDH)

研究领域 >> 炎症/免疫

[体外研究]

Prunetin通过灭活人鼻上皮细胞TLR4/MyD88通路,抑制LPS诱导的炎性细胞因子产生和MUC5 AC的表达和分泌[1]。

[参考文献]

[1]. Hu H, et al. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomed Pharmacother. 2018 Oct;106:1469-1477.

[2]. Sheikh S, et al. Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin. Biochem Pharmacol. 1997 Feb 21;53(4):471-8.

樱黄素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
546.5±50.0 °C at 760 mmHg

[ 熔点 ]:
240-242ºC

[ 分子式 ]:
C₁₆H₁₂O₅

[ 分子量 ]:
284.263

[ 闪点 ]:
209.7±23.6 °C

[ 精确质量 ]:
284.068481

[ PSA ]:
79.90000

[ LogP ]:
3.53

[ 外观性状 ]:
奶油色、白色结晶粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.669

[ 储存条件 ]:
室温，惰性气体，密封

樱黄素MSDS

樱黄素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100050

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-

CAS REGISTRY NUMBER :: 552-59-0

BEILSTEIN REFERENCE NO. :: 0292155

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O5

MOLECULAR WEIGHT :: 284.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,51,1979

樱黄素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DJ3100050

[ 海关编码 ]:
2914509090

樱黄素合成路线

樱黄素上下游产品

樱黄素上游产品

樱黄素下游产品

樱黄素海关

[ 海关编码 ]: 2914509090

[ 中文概述 ]:
2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

樱黄素文献

Preparation and evaluation of surface-bonded tricationic ionic liquid silica as stationary phases for high-performance liquid chromatography.

J. Chromatogr. A. 1396 , 62-71, (2015)

Two tricationic ionic liquids were prepared and then bonded onto the surface of supporting silica materials through "thiol-ene" click chemistry as new stationary phases for high-performance liquid chr...

Absorption of red clover isoflavones in human subjects: results from a pilot study.

Br. J. Nutr. 103(11) , 1569-72, (2010)

In addition to soya-derived preparations, red clover-based dietary supplements have gained considerable interest as an alternative isoflavone (IF) source. While metabolism and bioavailability of the m...

The phytoestrogen prunetin affects body composition and improves fitness and lifespan in male Drosophila melanogaster.

FASEB J. 30 , 948-58, (2016)

Dietary isoflavones, a group of secondary plant compounds that exhibit phytoestrogenic properties, are primarily found in soy. Prunetin, a representative isoflavone, was recently found to affect cell ...

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樱黄素