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6-氨基-2-甲基-2-庚醇盐酸盐

6-氨基-2-甲基-2-庚醇盐酸盐用途

Heptaminol盐酸盐是一种血管收缩剂, 用于治疗低血压, 特别是体位性低血压。

6-氨基-2-甲基-2-庚醇盐酸盐名称

[ CAS 号 ]:
543-15-7

[ 中文名 ]:
盐酸庚胺醇

[ 英文名 ]:
6-amino-2-methylheptan-2-ol,hydrochloride

[中文别名 ]:

[英文别名 ]:

6-hydroxy-6-methyl-2-heptylamine hydrochloride
Heptylon tropfen
6-amino-2-methyl-2-heptanol hydrochloride
Heptamyl tropfen
Coreptil
MFCD00013015
6-Amino-2-methyl-heptan-2-ol,Hydrochlorid
Delmiton
Arcor tropfen
Cardiosintol

6-氨基-2-甲基-2-庚醇盐酸盐生物活性

[ 描述 ]:

Heptaminol盐酸盐是一种血管收缩剂, 用于治疗低血压, 特别是体位性低血压。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 心血管疾病

[参考文献]

[1]. Pourrias B, et al. Heptaminol chlorhydrate: new data. Ann Pharm Fr. 1991;49(3):127-138.

[相关活性小分子]

6-氨基-2-甲基-2-庚醇盐酸盐物理化学性质

[ 密度 ]:
0.895g/cm3

[ 沸点 ]:
250.1ºC at 760mmHg

[ 熔点 ]:
165-167 °C(lit.)

[ 分子式 ]:
C₈H₂₀ClNO

[ 分子量 ]:
181.70300

[ 闪点 ]:
105.1ºC

[ 精确质量 ]:
181.12300

[ PSA ]:
46.25000

[ LogP ]:
2.77710

[ 储存条件 ]:
2-8℃

6-氨基-2-甲基-2-庚醇盐酸盐MSDS

详细MSDS(安全技术说明书)

6-氨基-2-甲基-2-庚醇盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ3240000

CHEMICAL NAME :: 2-Heptanol, 6-amino-2-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 543-15-7

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H19-N-O.Cl-H

MOLECULAR WEIGHT :: 181.74

WISWESSER LINE NOTATION :: ZY1&3XQ1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 28 ug/kg

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP Kidney, Ureter, Bladder - urine volume increased Skin and Appendages - sweating

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,178,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,178,1951

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 670 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,515,1970

6-氨基-2-甲基-2-庚醇盐酸盐安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MJ3240000

[ 海关编码 ]:
2922199090

6-氨基-2-甲基-2-庚醇盐酸盐海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

6-氨基-2-甲基-2-庚醇盐酸盐文献

Metabolism of isometheptene in human urine and analysis by gas chromatography-mass spectrometry in doping control.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 827(2) , 199-204, (2005)

A study of the metabolism of isometheptene, an antispasmodic drug, in man and comparison with heptaminol metabolism, is presented in this paper. Isometheptene and two metabolites were detected in huma...

Double-blind plethysmographic study of venous effects of heptaminol adenosine phosphate in patients with primary varicose veins.

Eur. J. Clin. Pharmacol. 37(1) , 37-40, (1989)

Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. Strain gauge plethysmography ...

Measurement of lymphatic flow variation by noninvasive method cases of lymphedema.

Angiology 43(7) , 567-71, (1992)

The purpose of this study was to measure the variations of lymphatic flow. A noninvasive isotopic method was used to achieve a functional exploration of lymphatic circulation. Fifteen subjects were us...

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